Simultaneous colorectal and minor hepatic resections are safe and should be performed for most patients with SCRLM. Due to increased risk of severe morbidity, caution should be exercised before performing simultaneous colorectal and major hepatic resections.
The overall bowel obstruction rate was unchanged; however, adhesive small-bowel obstruction requiring reoperation was significantly reduced by the use of Seprafilm, which was the only factor that predicted this outcome.
Accumulation of continuous life stress (chronic stress) often causes gastric symptoms. Although central oxytocin has antistress effects, the role of central oxytocin in stress-induced gastric dysmotility remains unknown. Solid gastric emptying was measured in rats receiving acute restraint stress, 5 consecutive days of repeated restraint stress (chronic homotypic stress), and 7 consecutive days of varying types of stress (chronic heterotypic stress). Oxytocin and oxytocin receptor antagonist were administered intracerebroventricularly (icv). Expression of corticotropin-releasing factor (CRF) mRNA and oxytocin mRNA in the paraventricular nucleus (PVN) of the hypothalamus was evaluated by real-time RT-PCR. The changes of oxytocinergic neurons in the PVN were evaluated by immunohistochemistry. Acute stress delayed gastric emptying, and the delayed gastric emptying was completely restored after 5 consecutive days of chronic homotypic stress. In contrast, delayed gastric emptying persisted following chronic heterotypic stress. The restored gastric emptying following chronic homotypic stress was antagonized by icv injection of an oxytocin antagonist. Icv injection of oxytocin restored delayed gastric emptying induced by chronic heterotypic stress. CRF mRNA expression, which was significantly increased in response to acute stress and chronic heterotypic stress, returned to the basal levels following chronic homotypic stress. In contrast, oxytocin mRNA expression was significantly increased following chronic homotypic stress. The number of oxytocin-immunoreactive cells was increased following chronic homotypic stress at the magnocellular part of the PVN. Icv injection of oxytocin reduced CRF mRNA expression induced by acute stress and chronic heterotypic stress. It is suggested that the adaptation mechanism to chronic stress may involve the upregulation of oxytocin expression in the hypothalamus, which in turn attenuates CRF expression.
T here has been a movement recently to bring to bear on the conduct of philosophical thought experiments (henceforth "thought experiments") 1 the empirical techniques of the social sciences, that is, to treat their conduct as in the nature of an anthropological investigation into the application conditions of the concepts of a group of subjects. This is to take a third person, in contrast to the traditional first person, approach to conceptual analysis. This has taken the form of conducting surveys about scenarios used in thought experiments. 2 It has been called "experimental philosophy" by its practitioners and has been applied across a range of fields: the philosophy of language, the philosophy of action, the philosophy of mind, epistemology, and ethics. 3 The results of these surveys have been used to support conclusions about the application conditions of particular concepts of interest in philosophy. They have also been used to support (and been motivated by) skeptical claims about the traditional approach to conceptual analysis. The 1. I mean to distinguish philosophical thought experiments, which aim at the elucidation of concepts, in a sense to be further explained, from scientific thought experiments, whose aim is to draw out consequences of empirical theories of the world.2. Many of the themes expressed by proponents of "experimental philosophy" are similar to those expressed by Arne Naess in his early work, especially in Interpretation and Preciseness (1953), which presents a wealth of empirical information about ordinary usage in the form of surveys, along with analysis.
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