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Volumetric and viscometric properties of glycine and methionine (amino acids) in a 0.2 vol. % amikacin sulphate (antibiotic drug) aqueous solution with the molality range of 0.025 mol kg−1–0.25 mol kg−1 were measured over the temperature range of 20°C–40°C at the interval of 5°C. Different parameters like apparent molar volume (ϕ V), apparent molar adiabatic compression (ϕ κ), isentropic compression (κ S) along with other acoustical parameters were calculated. Parameters like viscous relaxation time (τ), free volume (V F), internal pressure (Π I), and molar cohesive energy (MCE) were calculated from dynamic viscosity measurements. The ϕ V values are positive in both cases, but with higher magnitude observed in methionine. These positive values of ϕ V are indicative of strong solute-solvent interactions at all temperatures. In case of methionine there is a sharp initial increase in the ϕ V values which become almost constant with further additions of the amino acid. Structural differences in the two amino acids studied are clearly reflected in the different nature of the plots of different parameters. In case of an amino acid-drug system, dynamic viscosity increase has been attributed to the increase in the hydrophilic-ionic and hydrophilic-hydrophilic interactions with the increase in the amino acid concentration which in turn may cause more frictional resistance to the flow of the solution. All other parameters are discussed in terms of solute-solvent and solvent-solvent interactions.

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Pegivirus, HPgV, earlier known as Gb virus and hepatitis G virus, is an enveloped, positive-stranded RNA and lymphotropic virus classified into the Flaviviridae family. The transmission routes primarily involve blood products, with infections worldwide, leading up to 25% of persistent infections. To date, no effective therapeutic means are available to resolve Pegivirus infections. Effective vaccine therapeutics are the best alternative to manage this disease and any associated potential pandemic. Thus, whole proteome-based mining of immunogenic peptides, i.e., CTL (cytotoxic T lymphocytes), HTL (helper T lymphocytes) and B cell epitopes were mapped to design a vaccine ensemble. Our investigation revealed that 29 different epitopes impart a critical role in immune response induction, which was also validated by exploring its physiochemical properties and experimental feasibility. In silico expression and host immune simulation using an agent-based modeling approach confirmed the induction of both primary and secondary immune factors such as IL, cytokines and antibodies. The current study warrants further lab experiments to demonstrate its efficacy and safety.

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In this paper, we investigate the behavior of anisotropic compact stars in generalized modified gravity, namely [Formula: see text] gravity, where [Formula: see text] represents the Ricci scalar, [Formula: see text] is the scalar potential function and [Formula: see text] is a kinetic term of [Formula: see text]. We consider the spherically symmetric spacetime to analyze the feasible exposure of compact stars. We observe the behavior of anisotropic compact stars which includes Her X1, SAX J 1808.4-3658 and 4U 1820-30. From the graphical evaluation of energy density, tangential pressure, radial pressure, equilibrium conditions, energy conditions, mass–radius relationship, compactness and stability analysis of compact stars, it is concluded that the behavior of candidates of compact stars is regular in [Formula: see text] gravity for the considered parameter.