Background: Leprosy is a chronic infectious granulomatous disease caused by Mycobacterium leprae. The disease mainly affects peripheral nervous system, the skin and other tissues such as the muscles, bones and joints, eyes, reticuloendothelial system, testis etc. To reduce global load of leprosy, it is essential to have an early and proper diagnosis by clinical and histopathological correlation followed by proper and complete treatment. Aims and Objectives were 1) to study histopathological spectrum of various subtypes of leprosy, 2) to study the age and gender wise incidence of different subtypes of leprosy, and 3) to assess the concordance between clinical and histological diagnosis in cases of leprosy using Ridley-Jopling scale.Methods: A retrospective observational study of 126 skin biopsies diagnosed as leprosy over a period of one year from August 2020 to July 2021 at P. D.U. Medical College and Hospital, Rajkot, Gujarat.Results: In this study, most of cases occurred in age group (21-40) years (50.8%) and showed marked male predominance with M:F ratio=2.7:1. Lepromatous leprosy (40.5%) was the most common histopathological type of leprosy. Maximum clinicopathological correlation seen in HL (100%), LL (90%) and TT (71.4%).Conclusions: Histopathological examination of skin biopsies and clinicopathological correlation both are essential for early and accurate diagnosis and typing of leprosy which is helpful in prevention of deformities and drug resistance by early and appropriate treatment.

Background: Abnormal uterine bleeding (AUB) is defined as a pattern of bleeding that does not correspond with the duration, amount and frequency of the flow of a normal menstrual cycle. The cause of AUB varies according to the age, endometrial response to hormones and its variations and other structural lesions. Endometrial sampling by endometrium curettage is safe and easy technique and its histopathological analysis is considered the gold standard for diagnosis of the etiology of AUB. Aims and objective was to evaluate the spectrum of endometrial histology in cases of AUB, to find out age wise incidence of AUB, and to find out age wise incidence of various histological pattern of endometrium in AUB.Methods: An observational study was conducted on dilatation and curettage material which were obtained from 110 women with a complaint of AUB attending the gynecology outpatient department (OPD) at tertiary care hospital, Rajkot, Gujarat during one year (August 2020 to July 2021).Results: Maximum number of cases of AUB were noted in the age group of (31-40) years (44 cases, 40%). Most common observed histopathological pattern in this study was normal cyclical patterns including proliferative endometrium (34.5%) and secretory endometrium (21%).Conclusions: Histopathological evaluation of endometrium is indicated in women over the age of 35 years presenting with AUB to rule out preneoplastic lesions and malignancies.

No abstract