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IntroductionDiseases of prostate gland are important source of morbidity and mortality in male patients. The number of cases has continuously increased over the past decades, partly due to the higher life expectancy. The spectrum of diseases consists of inflammatory conditions, hyperplasia and malignancy. Prostate biopsy is essential to detect cancer and other benign conditions. There are other modalities of diagnosis, comprising of radiology and prostatic biomarkers. However, biopsy with histopathological examination is the gold standard for final diagnosis. Aims and Objectives 1. To study the incidence, age distribution, gross and histopathological features of lesions of prostate. 2. To classify tumours of prostate as per recommendations of WHO and to analyse cases of Adenocarcinoma of prostate according to Modified Gleason grading system. Materials and methods: Total 160 cases of prostatic lesions from June 2019 to December 2019 including needle core biopsy and TURP chips were evaluated in this study. The received specimens were fixed in 10% neutral buffered formalin and routine paraffin processing followed by hematoxylin and eosin staining. All specimens were analysed with the following parameters: type of specimen, age, medical history, histopathological examination and final diagnosis. Results and Conclusion:In the study of 160 cases, most common age group affected was 61-70 years. The youngest patient was 49 years old and the oldest was 90 years old. In our study, various histopathological patterns were observed, where BPH was the most common finding. We reported 23 cases of adenocarcinoma of prostate with application of modified Gleason grading system. Maximum number of cases of adenocarcinoma were seen in 61-70 years age group. It is necessary to study all prostate biopsies in order to identify premalignant lesions, proliferative activity and grade of inflammation. Histopathological diagnosis and grading play a definitive role in the management of prostatic carcinoma.

Background: Carcinoma of prostate is one of common tumors of old age in men. With digital rectal examination (DRE) prostate-specific antigen (PSA) is a major screening tool for prostate cancer. While Trans Rectal Ultra Sound (TRUS)guided needle biopsies of prostate are considered gold standard for the diagnosis of prostate cancers. Objectives: To determine the spectrum of pathological lesions in TRUS-guided needle biopsies of prostate in men with increased serum PSA levels (≥ 4 ng/ml) with or without symptoms of prostatism.

Background: The etiologies of thrombocytopenia are diverse. Various studies on thrombocytopenia are done in the past have related to specific etiologies. Objectives: This study attempts to determine the common etiologies of thrombocytopenia in adult patients admitted to Civil Hospital, Ahmedabad. Material and Methods: A cross-sectional study was carried out at Civil Hospital, Ahmedabad. Patients with thrombocytopenia more than 18 years of age at admission between 1 October and 31 October 2013 were followed up during their stay in hospital, diagnosis were made, and bleeding manifestations and requirement of platelet transfusion were recorded. Results: From the 412 patients studied, dengue was diagnosed in 28.6% of patients followed by malaria in 22.8%, chronic liver disease in 15.2%, hypersplenism in 12.3%, septicemia in 6.3%, gestational thrombocytopenia and disseminated intravascular coagulation in 5.5%, immune thrombocytopenic purpura (ITP) in 3.1%, megaloblastic anemia in 1.9%, human immunodeficiency virus in 1.4%, drug-induced thrombocytopenia in 1.2%, leukemia in 0.7%, and aplastic anemia in 0.48%. Bleeding secondary to thrombocytopenia was seen in 46 (11.2%) patients; of them, 28 were diagnosed with dengue fever, 4 with chronic liver disease, 3 with sepsis, 2 with hematological malignancies, and 9 with ITP. The common bleeding manifestations were gum bleed, purpura, petechial rash, and bruising. All the cases with platelet count o5,000/mL had bleeding manifestations secondary to thrombocytopenia. From the patients studied, 79.3% had fever associated with thrombocytopenia. Platelet transfusion was given to 87 patients: of these, 46 (52.8%) were transfused because of bleeding and 41 (47.1%) were given prophylactic transfusion. Conclusion: Dengue fever was the most common cause of thrombocytopenia and the most common etiology found in patients who had bleeding secondary to thrombocytopenia with gum bleed as a common manifestation. There was no definitive trigger value of platelet for platelet transfusion, and transfusion because of bleeding and prophylactic transfusion were given in almost similar proportions of patients.

14 years or less, where little variation is observed. [2-7] Though the etiology of testicular cancers is not well understood, various factors such as cryptorchidism, trauma, infections, and genetic and endocrine factors appear to have a role in their development. [8] A definite geographic and racial distribution is seen in testicular tumors. The age distribution of testicular cancers is also distinct from other types of cancer. [2] Objective: The purpose of this study was to analyze the pattern and distribution of testicular tumors in B.J. Medical College Ahmedabad, Gujarat, one of the tertiary health care institute in Northwest part of India. Materials and Methods This was a retrospective study in which cases were retrieved from the electronic database of the department of pathology, B.J. Medical College, Ahmedabad for patients Background: Testicular cancers are rare in most countries. However, in many Western countries their incidence has been increasing since the middle of the twentieth century. A definite geographic and racial distribution is seen in the occurrence of testicular tumors.