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SummaryFour chiral stationary phases containing modified cyclodextrins diluted in or chemically bonded to a non-chiral phase were used to resolve chiral organochlorine compounds such as a-hexachlorocyclohexane (a-HCH), perdeuterated a-HCH (a-PDHCH), p-and y-pentachlorocyclohexene (PCCH), oxychlordane, cis-and transchlor-dane, cis-and trans-heptachlorepoxide, PCB 95, PCB 132, PCB 149, and chiral toxaphenes. The elution order was determined by analyzing standards with known enantiomeric excesses. Furthermore, an internal standard was used to even out slight variations in the ratio of peak heights of enantiomers which were determined from injection to injection. None of the chiral stationary phases resolved all chiral organochlorine compounds. However, the P-TBDM (35% heptakis (6-0-t- butyldimethylsilyl-2,3-di-0-methyl)-~-cyclodextrin in OV 1701)column allowed the separation of all compounds under investigation except for PCB 95 and chiral toxaphenes. Emphasis was placed on the separation of as many as possible enantiomers on a chiral phase by application of one temperature program and with respect to unambiguous quantitation of biological samples such as blubber and liver of marine and terrestrial mammals.

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