Organochlorine residues in two seal species from Western Iceland

Vetter, Walter; Hummert, Kerstin; Luckas, Bernd; Skírnisson, Karl

doi:10.1016/0048-9697(95)04625-0

Cited by 29 publications

(12 citation statements)

References 7 publications

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“…PCBs and their hydroxylated metabolites have been identified in tissues [229][230][231][232][233][234][235]237,[248][249][250][251][252], and these compounds specifically alter thyroid homeostasis in other mammals [112,113,246,247]. PCBs and their hydroxylated metabolites have been identified in tissues [229][230][231][232][233][234][235]237,[248][249][250][251][252], and these compounds specifically alter thyroid homeostasis in other mammals [112,113,246,247].…”

Section: Mammalsmentioning

confidence: 99%

Gender Benders at the Beach: Endocrine Disruption in Marine and Estuarine Organisms

Oberdörster¹,

Cheek²

2001

Environ Toxicol Chem

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Several consensus definitions of the term endocrine disruptor have appeared recently, but all definitions include the important, though frequently implicit, stipulation that the animal is not distressed or in obvious discomfort. Instead, a superficially healthy animal is experiencing alterations in hormone synthesis, transport, receptor interaction, metabolism, excretion, or feedback regulation. In addition, hormone disruption may occur during sex differentiation, and its effects may not be manifested until after sexual maturation. Many cases of chemically induced reproductive impairment have been reported for both freshwater and marine species. However, reproductive impairment may not necessarily result from hormone disruption and should be considered suggestive, but not conclusive, evidence of endocrine disruption. A suite of in vivo and in vitro assays will more adequately assess whether a compound is truly endocrine disrupting. This review will cover basic endocrinology of marine and estuarine invertebrates and vertebrates, methods for detecting endocrine disruption, and examples of endocrine disruption in various species.

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Section: Mammalsmentioning

confidence: 99%

Gender Benders at the Beach: Endocrine Disruption in Marine and Estuarine Organisms

Oberdörster¹,

Cheek²

2001

Environ Toxicol Chem

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“…The chromatographic purity has been used in environmental science (25)(26)(27), partly under the term "enantiomer fractions." The chromatographic purity has been used in environmental science (25)(26)(27), partly under the term "enantiomer fractions."…”

Section: Vettermentioning

confidence: 99%

Enantioselective Fate of Chiral Chlorinated Hydrocarbons and Their Metabolites in Environmental Samples

Vetter

2001

Food Reviews International

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Gas chromatographic enantioseparation of chiral organochlorines (α-HCH, cis-and trans-chlordane, heptachlor, heptachlor epoxide, oxychlordane, o, p -DDT, compounds of technical toxaphene, stable atropisomeric PCBs and methylsulfonyl-PCBs) has been achieved during the last decade. For this purpose chiral stationary phases based on cyclodextrin derivatives have been applied in combination with GC/ECD, GC/MS, MDGC, and MS/MS. With these techniques methods have been developed which have been used to study the enantioselective fate of the chiral organochlorines. Changes in the enantioratios and conclusions drawn are reviewed. phenomenon of plane-polarized light (Malus, 1809) and optical rotation (Biot,113

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“…Recently, high chlordane levels were determined in seal blubber from Iceland confirming that chlordane is a major contaminant in this region [20].…”

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confidence: 99%

Gas chromatographic separation of chiral organochlorines on modified cyclodextrin phases and results of marine biota samples

Vetter

Klobes

Hummert

et al. 1997

J. High Resol. Chromatogr.

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SummaryFour chiral stationary phases containing modified cyclodextrins diluted in or chemically bonded to a non-chiral phase were used to resolve chiral organochlorine compounds such as a-hexachlorocyclohexane (a-HCH), perdeuterated a-HCH (a-PDHCH), p-and y-pentachlorocyclohexene (PCCH), oxychlordane, cis-and transchlor-dane, cis-and trans-heptachlorepoxide, PCB 95, PCB 132, PCB 149, and chiral toxaphenes. The elution order was determined by analyzing standards with known enantiomeric excesses. Furthermore, an internal standard was used to even out slight variations in the ratio of peak heights of enantiomers which were determined from injection to injection. None of the chiral stationary phases resolved all chiral organochlorine compounds. However, the P-TBDM (35% heptakis (6-0-t- butyldimethylsilyl-2,3-di-0-methyl)-~-cyclodextrin in OV 1701)column allowed the separation of all compounds under investigation except for PCB 95 and chiral toxaphenes. Emphasis was placed on the separation of as many as possible enantiomers on a chiral phase by application of one temperature program and with respect to unambiguous quantitation of biological samples such as blubber and liver of marine and terrestrial mammals.

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Organochlorine residues in two seal species from Western Iceland

Cited by 29 publications

References 7 publications

Gender Benders at the Beach: Endocrine Disruption in Marine and Estuarine Organisms

Gender Benders at the Beach: Endocrine Disruption in Marine and Estuarine Organisms

Enantioselective Fate of Chiral Chlorinated Hydrocarbons and Their Metabolites in Environmental Samples

Gas chromatographic separation of chiral organochlorines on modified cyclodextrin phases and results of marine biota samples

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