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We investigated the inhibitory effect of clarithromycin, a 14-membered ring macrolide antibiotic, on tumor-induced angiogenesis in vivo using a mouse dorsal air sac model. The inhibitory effect of clarithromycin was dose-dependent, and 100 mg/kg of clarithromycin administered intraperitoneally twice a day reduced the area of dense capillary network to about 30% that of the control. However, in concentrations up to 50 microM clarithromycin had no effect on lung cancer cells and human vascular endothelial cell growth, endothelial cell migration, or lung cancer cell production of the angiogenesis-inducing factors interleukin-8 and vascular endothelial growth factor. Clarithromycin in concentrations greater than 10 microM inhibited endothelial cell tube formation on Matrigel in a dose-dependent manner. These data suggest clarithromycin is a potent inhibitor of tumor-induced angiogenesis that exerts its effect by inhibiting endothelial cell tube formation, and may be a possible candidate for therapeutic application.

The expression of GST-Pi in NSCLC patients was significantly related to response to cisplatin-based chemotherapy, and may be a useful predictor of chemotherapy response.

Although the heart rate variability (HRV) values in adults decrease with aging, those in children show a variety of changes. The present study was designed to investigate the relationship between HRV and aging, physique and blood pressure in 70 healthy male school children, between 6 and 12 years of age. The subjects were divided into 3 age groups (6-7, 8-9 and 10-12 years) and 3 other groups according to physique (thin, under -10%; normal, -10-20% and obese, over 20% of obesity index). After recording a 24-h ambulatory electrocardiograph, HRV was determined spectrally, using 3 components: the total-frequency (TF) component (0.01 to 0.5 Hz), the low-frequency (LF) component (0.04 to 0.15 Hz), the high-frequency (HF) component (0.15 to 0.5 Hz) and also a two component ratio (LF/HF). The HRV values between the 3 age groups had a significant effect on TF, LF and LF/HF during the 24-h period, with the values increasing with age. The HRV values between the 3 physique groups had no significant effect. Therefore, changes in HRV in school children are affected by age and not physique. It is possible that the increase in HRV values with age is caused by the development of the autonomic nervous system.