The expression of GST-Pi in NSCLC patients was significantly related to response to cisplatin-based chemotherapy, and may be a useful predictor of chemotherapy response.
To determine the predictive value of the expression of p53 and glutathione S-transferase-π (GST-π) with respect to chemotherapy response, immunostaining was performed on transbronchial biopsy specimens from previously untreated patients with non-small cell lung cancer. Of the 54 patients, 34 patients (63%) and 37 patients (69%) were positive for p53 and GST-π, respectively. The response rates in the p53-positive and p53-negative group were 15 and 45%, and those in GST-π-positive and GST-π-negative groups were 16 and 47%, respectively. A multiple logistic regression analysis revealed that positive immunostaining for GST-π was a significant risk factor for clinical chemotherapy resistance. The combination of these two markers was the most important independent factor in predicting a response to chemotherapy in multiple logistic regression analysis. Immunohistochemical expression of p53 and GST-π was independently related to clinical chemoresistance in patients with non-small cell lung cancer. Combined use of these two biomarkers may be a useful predictor of clinical chemoresistance.
An acousto-optically Q-switched Nd:YVO(4)/KTiOAsO(4) (KTA) intracavity optical parametric oscillator (OPO) is efficiently realized in singly resonated scheme. With an end-pumping diode power of 25.9 W, output signal (1535 nm) power of 3.77 W and idler power (3467 nm) of 1.18 W are obtained at a pulse repetition rate of 50 kHz. A rate-equation model is set up to simulate the output power and time characteristics of both signal and idler waves. And both the numerical and experimental results show that the idler pulse width is shorter than the signal one in a singly resonant OPO.
A 1123 nm ceramic Nd:YAG laser passively Q-switched by graphene grown on SiC wafer was demonstrated. With a pump power of 8.1 W, an average output power of 332 mW was obtained, corresponding to an optical-to-optical conversion efficiency of 4.1% and a slope efficiency of 7.8%. The pulse width was 875.7 ns with a pulse repetition rate of 46.8 kHz.
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