This review gives a short overview on the widespread use of nanostructured and nanocomposite materials for disease diagnostics, drug delivery, imaging and biomedical sensing applications. Nanoparticle interaction with a biological matrix/entity is greatly influenced by its morphology, crystal phase, surface chemistry, functionalization, physicochemical and electronic properties of the particle. Various nanoparticle synthesis routes, characteristization, and functionalization methodologies to be used for biomedical applications ranging from drug delivery to molecular probing of underlying mechanisms and concepts are described with several examples (150 references).
A single-step, template-free aerosol chemical vapor deposition (ACVD) method is demonstrated to grow well-aligned SnO 2 nanocolumn arrays. The ACVD system parameters, which control thin film morphologies, were systematically explored to gain a qualitative understanding of nanocolumn growth mechanisms. Key growth variables include feed rates, substrate temperature, and deposition time. System dynamics relating synthesis variables to aerosol characteristics and processes (collision and sintering) are elucidated. By adjusting system parameters, control of the aspect ratio, height, and crystal structure of columns is demonstrated. A self-catalyzed (SnO 2 particles) vapor-solid (VS) growth mechanism, whereby a vapor-particle deposition regime results in the formation of nanocrystals that act as nucleation sites for the preferential formation and growth of nanocolumns, is proposed and supported. Density functional theory (DFT) calculations indicate that the preferential orientation of thin films is a function of the system redox conditions, further supporting the proposed VS growth mechanism. When taken together, these results provide quantitative insight into the growth mechanismIJs) of SnO 2 nanocolumn thin films via ACVD, which is critical for engineering these, and other, nanostructured films for direct incorporation into functional devices.
We demonstrated room-temperature gas sensing of volatile organic compounds (VOCs) using SnO nanostructured thin films grown via the aerosol chemical vapor deposition process at deposition temperatures ranging from 450 to 600 °C. We investigated the film's sensing response to the presence of three classes of VOCs: apolar, monopolar, and biopolar. The synthesis process was optimized, with the most robust response observed for films grown at 550 °C as compared to other temperatures. The role of film morphology, exposed surface planes, and oxygen defects were explored using experimental techniques and theoretical calculations to improve the understanding of the room-temperature gas sensing mechanism, which is proposed to be through the direct adsorption of VOCs on the sensor surface. Overall, the improved understanding of the material characteristics that enable room-temperature sensing gained in this work will be beneficial for the design and application of metal oxide gas sensors at room temperature.
A crumpled graphene oxide-SnO 2 nanocolumn (CGO-SnO 2 ) composite electrode was fabricated using aerosol-based techniques. First, SnO 2 nanocolumn thin films were fabricated using an aerosol chemical vapor deposition (ACVD) technique. The surface of the nanocolumn was then decorated with CGO by electrospray deposition. The CGOSnO 2 electrode was utilized for the electrochemical detection and determination of the free chlorine concentration in aqueous solutions using linear sweep voltammetry (LSV) and amperometric i-t curve techniques. The CGO-SnO 2 electrodes worked through the direct electrochemical reduction of hypochlorite ions (ClO -) on the surface of the electrode, which was used to determine the free chlorine concentration. The electrodes operate over a wide linear range of 0.1-10.08 ppm, with a sensitivity of 2.69 lA lM -1 cm -2 . Further, selectivity studies showed that these electrodes easily conquer the electrochemical signals of other common ions in drinking water distribution systems, and only shows the electrochemical reduction signals of free chlorine. Finally, the CGO-SnO 2 electrodes were successfully employed for the detection of free chlorine in tap water solutions (St. Louis, MO 63130, USA) with a sensitivity of 5.86 lA lM -1 cm -2 . Overall, the sensor fabricated using simple and scalable aerosol-based techniques showed a comparable performance to previous studies on amperometric chlorine sensing using carbonbased electrodes.
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