Perspective on Nanoparticle Technology for Biomedical Use

Raliya, Ramesh; Chadha, Tandeep S.; Haddad, Kelsey; Biswas, Pratim

doi:10.2174/1381612822666160307151409

Cited by 71 publications

(55 citation statements)

References 129 publications

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“…There is a globally increasing interest in nanoparticles, due to their unique and versatile physical and chemical properties to pass biological barriers [ 1 , 2 , 3 ]. Especially, particles of 1–100 nm in size with defined characteristics were used in biomedical engineering [ 4 , 5 ] and, according to some reports, nanoscale materials, like metallic nano-gold, have been serving humans for different medical purposes already since 2500 BC [ 5 ]. Cobalt, nickel, iron, and iron oxide, such as maghemite (γ-Fe 2 O 3 ) and magnetite (Fe 3 O 4 ) nanoparticles, have been widely considered as the most suitable materials for medical applications, due to their superparamagnetic property.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Toxicity and Neural Uptake In Vitro and In Vivo of Superparamagnetic Iron Oxide Nanoparticles

Khalid

Asad

Henrich‐Noack

et al. 2018

IJMS

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Superparamagnetic iron oxide nanoparticles (SPIO-NPs) have great potential to be used in different pharmaceutical applications, due to their unique and versatile physical and chemical properties. The aim of this study was to quantify in vitro cytotoxicity of dextran 70,000-coated SPIO-NPs labelled/unlabelled with rhodamine 123, in C6 glioma cells and primary hippocampal neural cells. In addition, we analyzed the in vitro and in vivo cellular uptake of labelled SPIO-NPs. The nanoparticles, with average size of 10–50 nm and polydispersity index of 0.37, were synthesized using Massart’s co-precipitation method. The concentration-dependent cytotoxicity was quantified by using tetrazolium dye 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). Intracellular localization of SPIO-NPs was detected by confocal laser microscopy. In vivo confocal neuroimaging (ICON) was performed on male Wistar rats after intravitreal injection followed by ex vivo retina whole mount analysis. When used for in vitro testing concentrations in the range of diagnostic and therapeutic dosages, SPIO-NPs proved to be non-cytotoxic on C6 glioma cells for up to 24 h incubation time. The hippocampal cell culture also did not show impaired viability at low doses after 24 h incubation. Our results indicate that our dextran-coated SPIO-NPs have the potential for in vivo drug delivery applications.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Toxicity and Neural Uptake In Vitro and In Vivo of Superparamagnetic Iron Oxide Nanoparticles

Khalid

Asad

Henrich‐Noack

et al. 2018

IJMS

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“…Moreover, this type of information on GO is still lacking. The extensive production of GO has raised concern over its use (Raliya, Chadha, Hadad, & Biswas, ). GO is known to be toxic to bacteria (Liu et al, ), erythrocytes, fibroblasts, PC 12 cells (Liu et al, ), A549 cells (Chang et al, ), L929 cells (Cherian et al, ), Raw 264.7 cells (Zhao et al, ), HepG2 cells (Lammel, Boisseaux, Fernández‐Cruz, & Navas, ), PLHC1 cells (Lammel & Navas, ) and zebra fish (Chen et al, ).…”

Section: Introductionmentioning

confidence: 99%

Graphene oxide induces cytotoxicity and oxidative stress in bluegill sunfish cells

Srikanth

Sundar

Pereira

et al. 2017

J of Applied Toxicology

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Graphene oxide (GO) is considered a promising material for biological application due to its unique properties. However, the potential toxicity of GO to aquatic organism particularly bluegill sun fish cells (BF-2) is unexplored or remains poorly understood. GO-induced cytotoxicity and oxidative stress in BF-2 cells were assessed using a battery of biomarkers. Two different biological assays (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide and neutral red uptake were used to evaluate the cytotoxicity of GO on BF-2 cells. It was found that GO induced dose- and time-dependent cytotoxicity on BF-2 cells. BF-2 cells exposed to lower concentration of GO (40 μg ml ) for 24 induced morphological changes when compared to their respective controls. As evidence for oxidative stress lipid peroxidation, superoxide dismutase, catalase, reactive oxygen species and 8-hydroxy-2'-deoxyguanosine levels were increased and glutathione levels were found to decline in BF-2 cells after treatment with GO. Our findings demonstrate that GO when exposed to BF-2 fish cells cause oxidative stress.

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“…These nanostructures are currently being studied for many applications, including use as sensors, optical devices, nanogenerators, and transducers due to their distinctive semiconducting, piezoelectric, and optical properties [13,[26][27][28][29]. ZnO NPs are also being used in several biomedical applications, including bioimaging, drug delivery, and gene delivery [30][31][32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

Near Infrared-Activated Dye-Linked ZnO Nanoparticles Release Reactive Oxygen Species for Potential Use in Photodynamic Therapy

Nagi

Skorenko²,

Bernier

et al. 2019

Materials

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Novel dye-linked zinc oxide nanoparticles (NPs) hold potential as photosensitizers for biomedical applications due to their excellent thermal- and photo-stability. The particles produced reactive oxygen species (ROS) upon irradiation with 850 nm near infrared (NIR) light in a concentration- and time-dependent manner. Upon irradiation, ROS detected in vitro in human umbilical vein endothelial cells (HUVEC) and human carcinoma MCF7 cells positively correlated with particle concentration and interestingly, ROS detected in MCF7 was higher than in HUVEC. Preferential cytotoxicity was also exhibited by the NPs as cell killing was higher in MCF7 than in HUVEC. In the absence of irradiation, dye-linked ZnO particles minimally affected the viability of cell (HUVEC) at low concentrations (<30 μg/mL), but viability significantly decreased at higher particle concentrations, suggesting a need for particle surface modification with poly (ethylene glycol) (PEG) for improved biocompatibility. The presence of PEG on particles after dialysis was indicated by an increase in size, an increase in zeta potential towards neutral, and spectroscopy results. Cell viability was improved in the absence of irradiation when cells were exposed to PEG-coated, dye-linked ZnO particles compared to non-surface modified particles. The present study shows that there is potential for biological application of dye-linked ZnO particles in photodynamic therapy.

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Perspective on Nanoparticle Technology for Biomedical Use

Cited by 71 publications

References 129 publications

Evaluation of Toxicity and Neural Uptake In Vitro and In Vivo of Superparamagnetic Iron Oxide Nanoparticles

Evaluation of Toxicity and Neural Uptake In Vitro and In Vivo of Superparamagnetic Iron Oxide Nanoparticles

Graphene oxide induces cytotoxicity and oxidative stress in bluegill sunfish cells

Near Infrared-Activated Dye-Linked ZnO Nanoparticles Release Reactive Oxygen Species for Potential Use in Photodynamic Therapy

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