Chlorins with phenol units were dissolved
in water via complexation
with the solubilizing agents trimethyl-β-cyclodextrin and λ-carrageenan
using a high-speed vibration milling technique. The photodynamic activities
of the trimethyl-β-cyclodextrin (TMeβCD) and λ-carrageenan
complexes were similar to that of Photofrin. However, the λ-carrageenan
chlorin complexes were more stable in aqueous solutions than the TMeβCD–chlorin
complexes. Thus, λ-carrageenan-complexed chlorin would be more
suitable as a photosensitizer.
With minimal invasiveness
and spatiotemporal therapeutic effects,
photodynamic therapy is one of the most elegant strategies for achieving
effective tumor therapy. Herein, a facile preparation and thermal
process-triggered release of water-soluble photosensitizer 5,10,15,20-tetrakis(4-hydroxyphenyl)porphyrin
(THPP) has been developed using a thermoresponsive polysaccharide,
hydroxypropyl cellulose. Current systems using hydroxypropyl cellulose
enable manipulation of the loading capacity of THPP into a polymer
matrix and the size of the complex by varying the temperature of the
solution in preparation. Furthermore, current systems have enabled
the release of THPP using a heating process, mimicking the surrounding
of mitochondria, and have resulted in THPP potency as a mitochondria-targeted
photodynamic therapy.
With minimal invasiveness and spatiotemporal therapeutic effects, photodynamic therapy is one of the most promising candidates for cancer treatment. Here, we developed a facile self-assembled nanogel using photosensitizer-grafted polysaccharides called...
The
purpose of a drug delivery system is to efficiently deliver
drugs to a desired target, while simultaneously reducing the side
effects caused by these drugs and maximizing their efficacy. However,
in the manufacture of a drug delivery system, it is difficult to control
the amount of drug encapsulation. In this study, we developed a simple
formation process of self-assembled hydrogels that made it easier
to package the desired amount of anticancer drugs. A self-assembled
hydrogel was prepared by simply mixing transferrin, dithiothreitol,
and an anticancer drug in a salt solvent. The structural conditions
of the hydrogel were determined in order to control the concentration
of the transferrin protein, dithiothreitol, and salt in the solvent.
The self-assembled hydrogels contained the desired amount of anticancer
drugs. With this system, changes in pH and temperature control the
release rate and the release ratio of anticancer drugs. The cytotoxicity
of the drug-loaded hydrogel was evaluated, which showed that 80% of
the treated cells had been killed following 48 h of incubation.
A water solubilization technique using biocompatible polypeptides via a mechanochemical approach was developed for the issues in the pharmaceutical industry.
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