Water solubilization of paclitaxel using polypeptides for cancer therapy

Abstract

A water solubilization technique using biocompatible polypeptides via a mechanochemical approach was developed for the issues in the pharmaceutical industry.

Ultrasonic Film Rehydration Synthesis of Mixed Polylactide Micelles for Enzyme-Resistant Drug Delivery Nanovehicles

“…For the PLAMs–PTX sample, the intensive peak at 232 nm was found. According to the literature data for the PTX in THF, the peak at 230 nm corresponds to the absorption of PTX [ 73 ]. In Figure 10 , the UV–Vis spectrum of commercial Paclitaxel-Teva is presented.…”

“…So, the search for effective drug delivery forms for PTX is still challenging. The intravenous route of administration of PTX is the major method for treatment [ 72 , 73 , 78 , 79 ]. For this purpose, different carriers of amphiphilic and polymeric structures are developing [ 9 , 11 , 15 , 18 , 46 , 61 , 72 , 78 ].…”

Formulation of water-dispersible hydrophobic compound nanocomplexes with polypeptides via a supramolecular approach using a high-speed vibration milling technique

“…Complexes of hydrophobic compounds with solubilizers were prepared via HSVM, as previously reported. [15][16][17][18][19][20][21][22]35 Briey describing the procedure, solid mixtures of solubilizers and hydrophobic compounds were shaken with two agate mixing balls using a high-speed vibrating mill (25 Hz, 30 min), suspended in 2.0 mL of aqueous solution, and then centrifuged to collect the supernatant. Polypeptides, including PLL, PGA, and Col, were used as solubilizers.…”

“…[23][24][25][26][27][28][29][30][31][32][33][34] More recently, using polypeptides as solubilizers, we succeeded in solubilizing paclitaxel, a hydrophobic anticancer drug, in larger quantities compared to that using polysaccharides, which are conventional solubilizers. 35 The results encouraged us to investigate the applicability of polypeptides as water solubilizers.…”

“…With an excellent biocompatibility [23][24][25][26][27][28][29][30][31][32][33][34][35] and responsiveness to external stimuli, including enzymes, 23,24 pH, 25,26 and reactive oxygen species, 27 polypeptides have been used in various elds, including the biomedical eld, as drug delivery systems 23,27,29 and hydrogels. 24,[27][28][29] For example, poly-L-lysine (PLL), which is traditionally used as a coating agent for culture media to enhance the attachment of cells 30 and manipulate neuronal cellular fate, 31 has a primary amino group in its side chain, which contributes to structural changes associated with pH changes.…”