It has been generally recognized that in a living body various biochemical changes were induced as a consequence of hard physical exercise. In the previous paper (1), the authors reported on the metabolism of glucuronic acid in the case of fatigue by physical exercise.This report was summarized as follows : the toxic (amine-like) substance in a living body increased due to physical exercise, and resulted in fatigue. The glucuronic acid content of urine, serum, liver and kidney, and the hepatic glycogen content of a living body decreased. The activity of o-aminophenylglucuronide synthesis of rat's liver was inhibit ed after hard physical exercise. However, these phenomena were significantly blocked by the administration of glucuronolactone. The arrest of an isolated frog heart due to the accumulation of toxic substance was checked, both prophylactically and therapeu tically, by the administration of glucuronolactone. have recently proved that glucuronic acid exerted its effect after it was converted into uridine-diphospho-glucuronic acid. It is therefore apparent that exogenous glucuronic acid cannot exert its effect unless it is changed into uridine diphospho-glucuronic acid through the Xylulose pathway, or different pathway not yet known. Though the authors have no description of the mechanism of these pathway at present, it is a fact that glucuronolactone can inhibit the toxic substance which stopped the beating of a frog's heart.As well known, uridine-diphospho-glucuronic acid is converted from various kinds of carbohydrate, namely glucose, galactose, glycogen and sodium pyruvate. The authors therefore proceeded to ascertain the effects of these carbohydrates and glucuronolactone upon the swimming-record, o-aminophenylglucuronide synthesis, glucuronic acid content, ascorbic acid content, blood sugar content, hepatic glycogen content, and Q-D-glucuronide glucuronohydolase activity in albino rats made to swim hard.
A 56 year old female developed combined hepatocellular cholangiocarcinoma associated with dermatomyositis. Serum tumour markers except for carbohydrate antigen (CA 19-9; 6400 ng/ml) were within normal range. Despite extensive chemotherapy, no clinical response was obtained and the patient's course deteriorated after 4 months. Macroscopically, the liver was mainly occupied by hepatocellular carcinoma but cholangiocarcinoma was found in the hilum. This is the first case of a rare association of combined hepatocellular-cholangiocarcinoma and dermatomyositis.
Ffteen cases of peripheral T-cell lymphoma were studied to evaluate the respective properties of various histologic types using enzyme histochemical and ultrastructural examinations in addition to immunological methods. Eleven cases in an ATLA negative group manifested various histologic patterns such as IBL-like, pleomorphic and Lennert's lymphomas in comparison with the relatively monomorphic proliferation of neoplastic lymphoid cells in the 4 ATLA-positive cases. The presence of neoplastic clear cells is characteristic of peripheral T-cell malignancies, and is likely to be found in CD4+ lymphomas. There is an occasional reaction of epithelioid histiocytes and plasma cells with eosinophils, the former being designated Lennert's lymphoma and the latter IBL-like Tcell lymphoma. Immunological examination revealed four immunophenotypic patterns : (1) CD2+3+4+8-, (2) CD2+ 3-4+8-, (3) CD2+3+4-8+, and (4) CD2+3+4+8+, but did not provide information concerning the intimate relationship between histologic types and immuno-phenotyes. p-Glucuronidase reactivity, however, contributed to the distinction between helper and suppressor T-cell malignancies, suggesting its usefulness for distinguishing these two cell types and their malignant counterparts.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.