The eradication rate of V-AC treatment in the CAM-susceptible H. pylori-infected patients was <90%, as was that by PPI-AC, thus V-AC is not ideal regimen in CAM-susceptible H. pylori. However, the 82.9% eradication rate of V-AC in the CAM-resistant infections may indicate the potential of V-AC with modified dose, dosing interval, and treatment duration. (UMIN000016337).

A stress-induced substance(s) (factor C) incubated with norepinephrine (NE) has strong flower-inducing activity in Lemna paucicostata. We isolated an essential component (FIF) of factor C, and clarified its chemical structure as 9-hydroxy-10-oxo-12(Z),15(Z)-octadecadienoic acid, an alpha-ketol derivative of linolenic acid, which is formed via 9-hydroperoxy linolenic acid. Synthesized FIF showed flower-inducing activity after incubation with NE (factor C activity) equivalent to that formed in the stressed Lemna. Jasmonic acid and 13-hydroxy-12-oxo-9(Z),15(Z)-octadecadienoic acid (12,13-alpha-ketol linolenic acid), both of which are formed via 13-hydroperoxide of linolenic acid and all other derivatives of FIF synthesized by chemical and enzymatic processes failed to show the factor C activity. These results suggest that the molecular structure of FIF is very specific for the factor C activity.

SUMMARYBackground: In functional gastrointestinal (GI) disorders including functional dyspepsia (FD) and irritable bowel syndrome (IBS), there might be no small extent of contributions of psychosomatic factors. As a therapy for IBS patients, the effectiveness of antidepressants has been reported. Aim: In this study, we evaluated the efficacy of H 2 -receptor antagonist (famotidine) and 5-HT 4 receptor agonist (mosapride citrate). In addition, the effect of antidepressants was assessed as the second-step therapy. Methods: Patients complaining upper GI symptoms were diagnosed as FD excluding organic diseases. Randomized patients received 20 mg/day of famotidine or

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In this paper, a tool named CheCUDA is designed to checkpoint CUDA applications that use GPUs as accelerators. As existing checkpoint/restart implementations do not support checkpointing the GPU status, CheCUDA hooks a part of basic CUDA driver API calls in order to record the status changes on the main memory. At checkpointing, CheCUDA stores the status changes in a file after copying all necessary data in the video memory to the main memory and then disabling the CUDA runtime. At restarting, CheCUDA reads the file, re-initializes the CUDA runtime, and recovers the resources on GPUs so as to restart from the stored status. This paper demonstrates that a prototype implementation of CheCUDA can correctly checkpoint and restart a CUDA application written with basic APIs. This also indicates that CheCUDA can migrate a process from one PC to another even if the process uses a GPU. Accordingly, CheCUDA is useful not only to enhance the dependability of CUDA applications but also to enable dynamic task scheduling of CUDA applications required especially on heterogeneous GPU cluster systems. This paper also shows the timing overhead for checkpointing.