This study aimed to optimize the ratio of dioctyl 4-cyclohexene-1,2-dicarboxylate (DOTH) and di-isononylcyclohexane-1,2-dicarboxylate (DINCH V R ) for use as plasticizers in poly(vinyl chloride) (PVC) sheets. We also evaluated the biological safety of DOTH for its potential to be part of a safe PVC-based blood container. The suppression of hemolysis in mannitoladenine-phosphate / red cell concentrates (MAP/RCC) with DOTH/(DINCH V R -PVC) sheets and the elution of plasticizers from the sheets increased with higher DOTH compositions. The properties of the PVC sheet containing DOTH and DINCH V R in the ratio of 25:33 parts against PVC 100 parts as a weight were almost identical to the PVC sheet made of di (2-ethylhexyl) phthalate. From a subchronic toxicity test, DOTH did not show any adverse effects on all organs, including the testes, epididymis, liver, and kidneys. The no-observed-adverseeffect level was 300 mg/kg body weight/day in a rat. These results suggest that DOTH/DINCH
revealed that it depends much upon the nature of the metal ion as well as upon that of the ligand whether the quadri-co-ordinate complex of a transition element takes a squareplanar configuration or a configuration distorted from it. Thus, the stability of the tetrahedral co-ordination around the metal ion, as compared with that of the square-planar one, is higher for cobalt(II)1), a little lower for nickel(II)2), and much lower for copper(II)3).
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