SI-1. InstrumentsUV-vis spectra were obtained using a V-570 spectrometer (JASCO CO.). 1 H NMR spectra were recorded using a Joel jnm-GSX400 (400 MHz). The measurement was taken in CDCl 3 using tetramethylsilane (TMS) as an internal standard.
SI-2. Yield of Ni 50 Co 50Yield of Ni 50 Co 50 was calculated from the weight of the obtained powder. Ni 2+ (12.5 mmol) and Co 2+ (12.5 mmol) were used for the synthesis of Ni-Co nanoparticles. The composition in the obtained powder was confirmed as Ni 50 Co 50 from the ICP results. The weight of the obtained powder was 1.56 g. The weight percent of the surface modifying agents in the powder was 6.0 wt%, determined by TGA. Therefore, the yield of Ni 50 Co 50 -the amounts of Ni and Co atoms-was 99.5
A 51-year-old man presenting with radiculopathy a rare cervical dural arteriovenous fistula (AVF) is reported. Angiography revealed that the cervical dural AVF was fed mainly by the left C-3 and C-4 radicular arteries and drained into the internal vertebral venous plexus with no communication with intradural structures. The dural AVF was treated surgically after embolization therapy. Although the AVF showed mass effect on computerized tomography (CT) scanning, abnormal vessels, which were suspected to drain the AVF, were observed intraoperatively to compress the left C-4 and C-5 nerve root sleeves. After resection of these abnormal epidural vessels, monoparesis of the left proximal upper extremity was markedly improved. In this patient, dynamic CT scanning was useful in the initial diagnosis, and the preoperative embolization therapy was very effective.
Thirty-five parkinsonian patients (five untreated, six with levodopa only, seven with levodopa plus Ro 4-4602, nine with anticholinergic and/or antihistaminic medication, and eight with the anticholinergic/antihistaminic medication plus amantadine) and 35 age-matched control subjects were studied. Platelets isolated from each individual plasma were incubated with 14C-dopamine. Uptake was found to be decreased to a significant degree in all treated or untreated parkinsonian patients when compared with control subjects. Anticholinergic and/or antihistaminic medication, with or without amantadine, further decreased the dopamine uptake into platelets, while levodopa alone or with Ro 4-4602 returned uptake values to near normal. Dopamine efflux paralleled exactly the uptake values. The fact that parkinsonian platelets exhibit impaired dopamine uptake, while age-matched control platelets do not, constitutes the first direct evidence in favor of a generalized dopamine defect in Parkinson's disease.
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