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uNK cells from early human pregnancy decidua possess innate protease activity, especially MMP-2, providing further evidence for a role for these cells in regulation of trophoblast invasion and spiral artery remodeling in early placentation.

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In this report, we present the terminology, definition and classification of pregnancy induced hypertension (PIH) by the Japan Society for the Study of Hypertension in Pregnancy (JSSHP). PIH is classified as gestational hypertension (GH), preeclampsia (PE), superimposed preeclampsia (S-PE) or eclampsia (E). Subclassifications by symptoms (severity and gestational age at onset) are also shown. Hypertension Research In PregnancyKey words: definition, pregnancy induced hypertension, preeclampsia TerminologyIn 2004, "Toxemia of Pregnancy" was revised to "Pregnancy induced Hypertension (PIH)" in Japan. 1,2)Definition PIH is defined as hypertension (blood pressure ≥ 140/90 mmHg) with or without proteinuria ( ≥ 300 mg/24 hours) emerging after 20 weeks gestation, but resolving up to 12 weeks postpartum.1-10) PIH is also defined as new onset proteinuria ( ≥ 300 mg/24 hours) in hypertensive women who exhibit no proteinuria before 20 weeks gestation. Classification Gestational hypertension (GH)GH is diagnosed in women whose blood pressure reaches ≥ 140/90 mmHg for the first time during pregnancy (after 20 weeks gestation), but without proteinuria. Blood pressure normalizes by 12 weeks postpartum. Preeclampsia (PE)Hypertension (blood pressure ≥ 140 / 90 mmHg) accompanied with proteinuria exceeding 300 mg/24 hours emerges for the first time after 20 weeks gestation, but both symptoms normalize by 12 weeks postpartum. Superimposed preeclampsia (S-PE)Superimposed preeclampsia is diagnosed in the following three cases. (1) New onset proteinuria ( ≥ 300 mg/24 hours) in hypertensive women who exhibit no proteinuria before 20 weeks gestation. (2) Hypertension and proteinuria documented antecedent to pregnancy and/or detected before 20 weeks gestation, one or both of which progressing after 20 weeks gestation. (3) Renal disease with proteinuria documented antecedent to pregnancy and/or detected before 20 weeks gestation, which is accompanied with new onset hypertension after 20 weeks gestation. Eclampsia (E)Eclampsia is defined as the onset of convulsions in a woman with PIH that cannot be attributed to other causes. The seizures are generalized and may appear before, during, or after labor.Subclassification by symptoms *Severity* The severity of PIH is assessed by the extent of symptoms. Both blood pressure and proteinuria are dependable indicators of severity.

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The chemoresistance of CCA may be due to aberrant retention of the G2 checkpoint through overexpression of HNF-1β. This is the first study demonstrating cell cycle regulation and chemosensitization by a CHK1 inhibitor in CCA.