Peripheral blood concentrations of adiponectin, an adipocyte-specific plasma protein, in normal pregnancy and preeclampsia

Naruse, Katsuhiko; Yamasaki, Mineo; Umekage, Hideshi; Sado, Toshiyuki; Sakamoto, Yohko; Morikawa, Hajime

doi:10.1016/j.jri.2004.09.004

Cited by 108 publications

(92 citation statements)

References 36 publications

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“…Recent reports have demonstrated that plasma adiponectin concentrations are not elevated in normal human pregnancies, but are paradoxically elevated in women with PE, [25][26][27] although both PE and healthy pregnancies are characterised by an increase in insulin resistance. 28 Placental leptin production is elevated under hypoxic conditions, 29 and leptin levels in PE are significantly higher than in normal pregnancies, [30][31][32] suggesting that leptin derived from the placenta may play a role in the pathophysiology of PE through insulin resistance, autonomic activation or direct effects on the endothelium.…”

Section: Discussionmentioning

confidence: 99%

Different profiles of circulating angiogenic factors and adipocytokines between early‐ and late‐onset pre‐eclampsia

Masuyama

Segawa

Sumida

et al. 2010

BJOG

109

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Objective Circulating angiogenic factors have been shown to be important in the pathophysiology of pre-eclampsia. Blood levels of adipocytokines differ in pre-eclampsia relative to controls and may also play an important role in disease pathogenesis. Differences in the circulating levels of these molecules were compared between matched normotensive controls and women with pre-eclampsia with onset before or at/after 32 weeks, and according to whether the women were of normal weight (18.5 < body mass index < 25) or overweight.Design A cross-sectional study of 110 pregnant Japanese women who visited the Department of Obstetrics and Gynecology, Okayama University Hospital, Okayama, Japan.Setting Tertiary referral centre serving 2000 births.Methods Serum concentrations of soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF), soluble endoglin (sEng), adiponectin and leptin were measured in women with pre-eclampsia and in normotensive controls matched for age, gestational week, parity and body mass index.Main outcome measures Serum levels of sFlt-1, PlGF, the sFlt-1/ PlGF ratio, sEng, adiponectin and leptin.Results The sFlt-1/PlGF ratio in early-onset pre-eclampsia was significantly higher than that in late-onset pre-eclampsia (112.0 ± 30.2 versus 45.4 ± 43.8, P = 0.037). There was a significant elevation of leptin in both subtypes relative to controls (early: 58.6 ± 18.3 ng/ml versus 26.0 ± 6.7 ng/ml, P = 0.001; late: 39.5 ± 9.2 ng/ml versus 22.0 ± 4.3 ng/ml, P = 0.005), but adiponectin was increased only in late-onset pre-eclampsia (36.5 ± 13.4 lg/ml versus 12.0 ± 4.3 lg/ml, P = 0.003). Significant differences in angiogenic factors and adiponectin were found between normal and overweight women only in late-onset pre-eclampsia.Conclusions These data suggest that there are different profiles of angiogenic factors and adipocytokines between women who develop early-and late-onset pre-eclampsia.

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Section: Discussionmentioning

confidence: 99%

Different profiles of circulating angiogenic factors and adipocytokines between early‐ and late‐onset pre‐eclampsia

Masuyama

Segawa

Sumida

et al. 2010

BJOG

109

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“…También se ha reportado una fuerte asociación entre las bajas concentraciones de adiponectina y el riesgo de preeclampsia, por lo que se ha considerado que podría tener un papel predictor en los síndromes inducidos por el embarazo y, en especial, en la preeclampsia. Sin embargo, otras investigaciones no apoyan los resultados de esta investigación (6,(33)(34)(35)(36)(37).…”

Section: Tabla IV Análisis De Regresión Entre Las Concentraciones De unclassified

“…A diferencia de los resultados encontrados en este estudio, otros dos (34,35) demostraron que las preeclámpticas tienen concentraciones mas altas de adiponectina que las embarazadas normotensas, mientras que una más reciente confirma que las concentraciones de adiponectina aumentan en la preeclampsia (6). Por lo que parece que las concentraciones de adiponectina varían ampliamente en las preeclámpticas y en las embarazadas normotensas (35).…”

Section: Tabla IV Análisis De Regresión Entre Las Concentraciones De unclassified

“…Por lo que parece que las concentraciones de adiponectina varían ampliamente en las preeclámpticas y en las embarazadas normotensas (35). Ramsay y cols (36) reportaron la elevación de las concentraciones de adiponectina en las preeclámpticas comparado con los controles y sugirieron que la liberación de adiponectina durante el embarazo puede ser una respuesta fisiológica para reducir la acumulación de grasa en las preeclámpticas para disminuir el daño endotelial.…”

Section: Tabla IV Análisis De Regresión Entre Las Concentraciones De unclassified

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Adiponectina Plasmática en Preeclampsia Y Eclampsia

Mejia-Montilla

Reyna-Villasmil

Torres-Cepeda

et al. 2008

Rev. chil. obstet. ginecol.

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RESUMENAntecedentes: La adiponectina, una de las proteínas específicas del tejido adiposo, se ha considerado que mejora la sensibilidad a la insulina, inhibe la inflamación vascular y tiene efectos antiaterogénicas, ya que se correlacionan negativamente con la obesidad y dislipidemia. Objetivo: Comparar las concentraciones de adiponectina plasmática en eclámpticas, preeclámpticas y embarazadas normotensas. Método: Se incluyeron 30 pacientes con preeclampsia leve (grupo A), 30 pacientes con preeclampsia severa (grupo B) y 30 pacientes con eclampsia (grupo C). El grupo control fue seleccionado por tener edad e índice de masa corporal similar con los grupos en estudio y consistió en 35 embarazadas sanas (grupo D). Solo se incluyeron pacientes nulíparas. Las muestras de sangre se recolectaron antes del parto y en los grupos en estudio inmediatamente después del diagnóstico para la determinación de adiponectina plasmática. Resultados: Los valores más bajos de adiponectina se observaron en el grupo de pacientes eclámpticas junto con las preeclámpticas severas. Se encontraron valores mas altos en las preeclámpticas leves. Los grupos en estudio presentaron valores de adiponectina significativamente inferiores que los controles (p<0,05). El análisis de regresión lineal, mostró que los factores que afectaban significativamente la concentración plasmática de adiponectina fueron: contaje de plaquetas, ácido úrico y proteinuria en 24 horas (p < 0,05). Conclusión: Las pacientes eclámpticas y preeclámpticas presentan concentraciones de adiponectina plasmática más bajas que las embarazadas normotensas y es posible que esta disminución puede contribuir a la resistencia a la insulina y a la aterogénesis acelerada observada en la preeclampsia. PALABRAS CLAVE: Adiponectina, preeclampsia, eclampsia SUMMARYBackground: Adiponectin, a specific protein from adipose tissue, is considered that improves the sensibility to insulin, inhibits vascular inflammation and has antiatherogenic effects, cause it correlate negatively with obesity and dyslipidemia. Objective: To compare plasma adiponectin concentrations in eclamptic, preeclamptic and normotensive pregnant women. Method: There were included 30 patients with mild preeclampsia (group A), 30 patients with severe spreeclampsia (group B) and 30 patients with eclampsia (group C). A control group was selected for having similar age and body mass index to studied groups and consisted in 35 healthy pregnant women (group D). There were included only nuliparous patients. Blood samples were collected in all patients before delivery and in studied groups immediately after diagnosis for plasma adiponectin determination. Results: Lower values of adiponectin were observed in eclamptic patients together with severe preeclamptic patients. Higher values were found in mild preeclamptic patients. Studied groups presented significant lower values of adiponectin compared with controls (p<0.05). Linear regression analysis, found that factors who affected significantly plasma adiponectin concentrations were: p...

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“…Adipokines, such as adiponectin [9,58,60,62,64,75,97], resistin [77] and visfatin [65] have been implicated in metabolic adaptations to normal gestation, as well as in complications of pregnancy such as preeclampsia [3,12,13,22,27,29,35,67,68,72,78,84,88,95,98,102], SGA [39,56,103] preterm labor and others [38, 52-55, 57, 59, 61, 63, 64, 67, 76, 101].…”

Section: Introductionmentioning

confidence: 99%

227: Evidence for differential regulation of the adipokine visfatin in the maternal and fetal compartments in normal spontaneous labor at term

Mazaki‐Tovi

Romero

Vaisbuch

et al. 2009

American Journal of Obstetrics and Gynecology

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Peripheral blood concentrations of adiponectin, an adipocyte-specific plasma protein, in normal pregnancy and preeclampsia

Cited by 108 publications

References 36 publications

Different profiles of circulating angiogenic factors and adipocytokines between early‐ and late‐onset pre‐eclampsia

Different profiles of circulating angiogenic factors and adipocytokines between early‐ and late‐onset pre‐eclampsia

Adiponectina Plasmática en Preeclampsia Y Eclampsia

227: Evidence for differential regulation of the adipokine visfatin in the maternal and fetal compartments in normal spontaneous labor at term

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