Histoplasmosis is a systemic mycosis, endemic, of worldwide distribution, which is caused by inhaling the propagules of Histoplasma capsulatum, in which they lodge in the lungs and subsequently trigger the human infection that can spread through the body. The forms of clinical manifestations vary according to the degree of impairment of the immune system of the individual. Therefore, the present study aims to describe the clinical and laboratory aspects of Histoplasmosis, by understanding that, today, errors still occur when identifying this mycosis, which leads to the increase of mortality, so early diagnosis is essential for the quality of life of the individuals. The study was based on a bibliographic review, with a qualitative approach, of an exploratory type. Because Histoplasmosis is an opportunistic mycosis, capable of affecting different organs and tissues, better training of professionals is necessary, associated with the application of the correct diagnostic techniques. Thus, it is concluded that the diagnosis made through laboratory techniques, such as the mycological, serological, histopathological, molecular examination, are fundamental for the early and correct diagnosis of the individual, which will contribute to improve therapeutic action.
Vários estudos têm sido conduzidos almejando detectar a variedade de marcadores genéticos associados à resistência malárica. Este trabalho teve como objetivo descrever a relação da deficiência de glicose-6-fosfato desidrogenase na resistência do hospedeiro ao Plasmodium spp. Para isso, realizou-se uma revisão sistemática com metanálise, seguindo as orientações PRISMA. A estratégia de busca foi feita no Medline via Pubmed, Science Direct, Lilacs, Scopus e Google acadêmico. O risco de viés foi utilizado para avaliar cada artigo selecionado através da lista de verificação de avaliação crítica do Instituto Joanna Briggs. Posteriormente, em conjunto, os trabalhos foram avaliados através de Teste de Egger. No total, encontrou-se 638 artigos. Destes, 26 participaram da síntese qualitativa e 15 na quantitativa. Dos 26 estudos, 18 relataram haver relação entre o déficit enzimático e a resistência malária. Quanto aos resultados da metanálise, verificou-se que a deficiência de G6PD pode estar associado à resistência do indivíduo desenvolver a malária, principalmente em asiáticos e africanos. Portanto, os resultados deste artigo poderão auxiliar no desenvolvimento de novas estratégias terapêuticas para esta enfermidade, beneficiando a saúde pública mundial.
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