Megacolon in children: Manometry, histology and histochemistry.Ninety-six anorectftl manometric studies were performed in children with megacolon Sixteen patients had pressure records compatibles with Hirschsprung's disease: in twelve the rectal suction biopsy and study of acetylcholinesterase activity confirmed the diagnosis of aganglionosis.In two pacients with non conclusive manometry, acetylcholinesterase activity was highly positive: in one the diagnosis ofcolonicneuronal dysplasia through the study of succinic dehydrogenase was confirmed.
Acety Icholinesterase activity was measured in rectal biopsy specimens obtained from 34 children, 12 patients with a previous surgical procedure for Hirschspnmg's disease and 22 patients with chronic constipation. The nietbod and the results are described. It is suggested that the assay of aeetylcholinesterase activity in rec-tal biopsy material is a simple and quick procedure useful in the diagnosis of congenital intestinal aganglionosis.
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