No abstract

No abstract

SummaryWe describe an 11-year-old girl with a mild bleeding disorder since early childhood. The disorder was characterized by a prolonged bleeding time, and the patient’s platelets showed defective aggregation responses to thromboxane A2 (TXA2) mimetic U46619 and arachidonic acid. In contrast, the platelets showed normal responses to thrombin and Ca ionophore A23187. When the platelet TXA2 receptor was examined with the [3H]-labeled TXA2 agonist U46619, the equilibrium dissociation rate constants (kd) and the maximal concentration of binding sites (Bmax) of the patient's platelets were within normal ranges. Normal GTPase activity was also induced in the patient's platelets by stimulation with U46619, however, inositol 1,4,5-triphosphate (IP3) formation was not induced by U46619. These results suggested that the patient’s platelets had a defect in phospholipase C activation beyond TXA2 receptors.

No abstract

Background: The function of CD48, one of the pan leukocyte cell surface antigens, is not yet well understood. CD48 was recently shown to enhance the CD40-mediated activating signal to B lymphocytcs. As CD-IX is one of the activation antigens of monocytes. neutrophils and lymphocytes, a change of its expression on the cells could be expected in infectious diseases. Methods and results: Leukocytes from 27 healthy controls and 97 patients with various infectious diseaseswere stained with antiLCD48 antibody and analyzed by flow cytometry. On monocytes and neutrophils, the CD-18 expression w a s increased in all of the patients with varicella, measles, rubella, infectious mononucleosis. streptococcus tonsillitis, sepsis and appendicitis. On lymphocytes, a significant increase of CD48 wa5 also detected in the patients with the same diseases. except those with sepsis or appendicitis. The nornirtlization of increased CD4X expression was confirmed on monocytes at the convalescent phase. Conclusion: These data suggest that CD48 expression on leukocytes reflects the disease activity of infectious diseases. especially of viral infections.Key words actiiation antigen. CD48. infectious disease.Cell sur-ktce CD48 is une of the pan leukocyte antigens. It

No abstract

The enamel matrix derivative (EMD, Emdogain) was used for the purpose to obtain the periodontal regeneration on the denuded root-surfaces of the donor teeth in two cases of the immediate tooth-transplantation. The root-surfaces at the cervical portion of the teeth were denuded because of extrusion. The healthy periodontium of each tooth remained at the apical portion of the roots. The denuded root-surfaces were cleansed before extraction. Then, the donor teeth were gently extracted with forceps, administered EMD, and transplanted so that the denuded surfaces were covered by gingival flaps. After the transplantation, the mean probing attachment level (PAL) improved 3.2 mm and 1.5 mm, respectively. The mean probing pocket depth was within normal level. The actual supporting areas of the roots of the transplanted teeth increased and the teeth worked as the abutments of prosthetic bridges.

No abstract