Hypozincemia during fever may trigger febrile convulsion

Izumi, Yukitoshi; Ishii, K.; Akiba, Kaori; Hayashi, Takahashi

doi:10.1016/0306-9877(90)90073-n

Cited by 26 publications

(24 citation statements)

References 34 publications

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“…Although the pathophysiology of FS is still unknown1,13,16), several studies have indicated that multiple factors can be involved in the pathogenesis of FS, including genetic factors3) interleukin-1β35), iron36), and zinc37,38).…”

Section: Discussionmentioning

confidence: 99%

Selenium and leptin levels in febrile seizure: a case-control study in children

2013

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PurposeFebrile seizures (FS) are seizures that occur between the age of 6 and 60 months, but its pathophysiology still is not fully understood. There is limited information about the correlation between levels of selenium and leptin with FS. This study aimed to determine the relationship between serum levels of selenium and leptin in children with FS.MethodsThis case-control study was conducted in a University Hospital in Shahrekord, Iran, in 2011. The serum levels of selenium and leptin of 25 children with simple febrile seizure (case group) were compared with 25 febrile children without seizure (control group) in acute phase and after three months. The levels of serum selenium and leptin were measured by flame atomic absorption spectrophotometer and enzyme-linked immunosorbent assay method, respectively.ResultsIn acute phase, the mean serum level of selenium in case and control groups were 95.88±42.55 and 113.25±54.43 µg/dL, respectively, and difference was not significant (P=0.415), but after three months, this level had a significant increase in both groups (P<0.001). In acute phase, the mean serum leptin level in case and control groups were 0.94±0.5 and 0.98±0.84 ng/mL, respectively, but difference was not significant (P=0.405). After three months, serum leptin level had no significant change in both groups (P=0.882).ConclusionThese observations suggest that serum levels of selenium and leptin have not specific relation with FS but overllay is lower, however, further study is recommended. Also selenium level in stress and acute phase was significantly lower than recovery phase.

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Section: Discussionmentioning

confidence: 99%

Selenium and leptin levels in febrile seizure: a case-control study in children

2013

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“…However, existing literature both on the positive role of Zn in the pathogenesis of FS and serum/CSF Zn levels in FS children remain scarce as evident from last 20 years computerized literature search, which could not reveal sufficient information, except for a few reports that include one of ours (17) whereas pathogenicity of FS is yet not understood fully (1,2,11). So, such paucity of FS literature prompted us to re‐investigate this important but insufficiently explored area of childhood FS, particularly among the poorer communities like those in Bangladesh.…”

Section: Introductionmentioning

confidence: 99%

Zinc concentration in serum and cerebrospinal fluid simultaneously decrease in children with febrile seizure: Findings from a prospective study in Bangladesh

et al. 2008

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“…It is believed that the release of tumor necrosis factor (TNF) and interleukin during fever or tissue injury may result in reduction of serum zinc level, mostly due to shifting from blood to the liver [44]. Hypozincemia trigger the NMDA receptor which is one of the members of glutamate family receptor, so hypozincemia may play an important role in initiation of epileptic discharge [45]. Many studies have reported that the mean serum zinc level is significantly lower in children with febrile seizure [46].…”

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confidence: 99%

Assessment of the Level of GABA and Some Trace Elements in Blood in Children who Suffer from Familial Febrile Convulsions

Salah¹,

Abdelraouf²,

Abdelhameed³

et al. 2014

Open Access Maced J Med Sci

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Febrile seizure is one of the most common neurological problems during childhood. The etiology and pathogenesis of febrile seizure remain unknown. However, several factors such as vitamin B6 deficiency, electrolyte disturbances, and reduction in serum zinc, selenium, magnesium levels, and low gamma -aminobutyric acid (GABA) levels are thought to play a role in the pathogenesis of febrile seizure. The present study included twenty children from 10 families, 11 were male and 9 were female. Each family has at least 2 members with a history of febrile convulsion. All cases were subjected to the following: Determination of serum levels of copper, zinc, magnesium, selenium level in serum, and plasma level of γ-aminobytaric acid (GABA). Serum levels of selenium and GABA were statistically significantly low in comparison with controls. Serum copper was statistically significantly higher in cases than controls, while serum zinc showed no significant changes in the cases of febrile convulsion compared with the control group. The mean Zn level in the serum of febrile convulsion was found to be at lower level than in the control group. The serum magnesium was significantly low in cases than controls. The logistic regression model in our study shows that Selenium and Magnesium have protective effects, while Copper has causative effect.

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Hypozincemia during fever may trigger febrile convulsion

Cited by 26 publications

References 34 publications

Selenium and leptin levels in febrile seizure: a case-control study in children

Selenium and leptin levels in febrile seizure: a case-control study in children

Zinc concentration in serum and cerebrospinal fluid simultaneously decrease in children with febrile seizure: Findings from a prospective study in Bangladesh

Assessment of the Level of GABA and Some Trace Elements in Blood in Children who Suffer from Familial Febrile Convulsions

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