Gastric cancer (GC) is a global health problem and further studies of its molecular mechanisms are needed to identify effective therapeutic targets. Although some long noncoding RNAs (lncRNAs) have been found to be involved in the progression of GC, the molecular mechanisms of many GC-related lncRNAs remain unclear. In this study, a series of in vivo and in vitro assays were performed to study the relationship between FAM225A and GC, which showed that FAM225A levels were correlated with poor prognosis in GC. Higher FAM225A expression tended to be correlated with a more profound lymphatic metastasis rate, larger tumor size, and more advanced tumor stage. FAM225A also promoted gastric cell proliferation, invasion, and migration. Further mechanistic investigation showed that FAM225A acted as a miR-326 sponge to upregulate its direct target PADI2 in GC. Overall, our findings indicated that FAM225A promoted GC development and progression via a competitive endogenous RNA network of FAM225A/miR-326/PADI2 in GC, providing insight into possible therapeutic targets and prognosis of GC.

No abstract

No abstract

Background: Although tumor size (Ts) is regarded as the “T” stage of the Tumor-Node-Metastasis (TNM) staging system for many solid tumors, the prognostic impact in gastric cancer (GC) remains uncertain and conflicting. Methods: We enrolled 6960 eligible cases from the Surveillance, Epidemiology, and End Results (SEER) database. The X-tile program was used to select the best cutoff value of Ts. Then the Kaplan-Meier method and the Cox proportional hazards model were applied to examine the efficacy of Ts on prognostic prediction for overall survival (OS) and gastric cancer-specific survival (GCSS). The presence of nonlinear association was determined by restricted cubic splines (RCS). Results: Ts was divided into three groups: small size (≤ 2.5 cm), medium size (2.6-5.2 cm), and large size (≥ 5.3 cm). After adjusting by covariates, Ts larger than 2.5 cm predicted a worse prognosis; however, no survival difference on OS was suggested between the medium and large groups. Similarly, according to the adjusted RCS models, for tumors larger than 3.9 cm, large tumor size showed no significant differences on OS and GCSS with those smaller. However, the stratified analyses proposed the usage of the 3-way cut of Ts in prognostic prediction for patients with both inadequate lymphadenectomy and negative lymph node metastasis. Conclusions: Ts as a prognostic predictor may not have good clinical applicability in GC. Otherwise, it is recommended for patients with both insufficient examination of lymph nodes and stage N0 disease.

Na0.5Bi4.5‐xCexTi4O15 (x = 0, 0.02, 0.04, 0.06, 0.08, 0.10) lead‐free piezoelectric ceramics with high Curie temperatures are fabricated using the conventional solid‐phase method. The effects of the Ce content on the phase structures, morphologies, and electrical properties of the Na0.5Bi4.5‐xCexTi4O15 ceramics are systematically investigated. The appropriate content of Ce increases b/a and c/a and induces the distortion of the crystal structure. The increased b/a leads to a transverse asymmetry of the Na0.5Bi4.5‐xCexTi4O15 ceramics, which facilitates the dipole flipping, thus enhancing the piezoelectric properties (d33 = 20 pC/N). Although the improved c/a increases the degree of tetragonality of the Na0.5Bi4.5‐xCexTi4O15 ceramic, which decreases the Curie temperature (TC), the TC values of all samples are higher than 600°C, considerably higher than the practical application temperature. The Ce doping significantly reduces the dielectric loss of the sample and increases its dielectric performance. The improvements in electric properties by the cerium doping can expand its use in high‐temperature environments for oilfield logging, aerospace, and military applications.

No abstract

No abstract

No abstract