Results MOG antibodies (median 1:2560; range 1:160-1:20 480) were detected in 19 children with ADEM. The majority of children showed a decline of serum MOG-IgG titres over time. Children with MOG antibodies did not differ in their age at presentation, sex ratio, the presence of oligoclonal bands, clinical symptoms or initial severity, apart from a higher CSF cell count ( p=0.038), compared with children without MOG antibodies. In addition, further relapsing demyelinating episodes associated with MOG antibodies were observed only in children with MOG antibodies. All 19 children with MOG antibodies had a uniform MRI pattern, characterised by large, hazy and bilateral lesions and the absence of atypical MRI features (eg, mainly small lesions, well-defined lesions), which was significantly different compared to that of children without MOG antibodies ( p=0.003; and p=0.032, respectively). In addition, children with MOG antibodies had involvement of more anatomical areas ( p=0.035) including the myelon characterised by a longitudinally extensive transverse myelitis ( p=0.003), more often a complete resolution of lesions ( p=0.036) and a better outcome ( p=0.038). Conclusions Patients with ADEM with MOG antibodies in our cohort had a uniform MRI characterised by large, bilateral and widespread lesions with an increased frequency of longitudinal extensive transverse myelitis and a favourable clinical outcome in contrast to children lacking MOG antibodies.

AIM: The aim of this study was to investigate the effect of oxidative stress on nucleosome levels and its relation with the clinical features in schizophrenia patients. MATERIAL AND METHOD: Thirty schizophrenia patients and 30 healthy controls were enrolled in this study. Patients were diagnosed with schizophrenia according to the 4th edition of the Diagnostic and Statistical Manual for Mental Disorders (DSM-IV). The control group consisted of 30 healthy subjects matched to the patients with regard to age and gender and who had no history of any psychiatric disorder. The severity of schizophrenia symptoms in the patients was evaluated using the Positive and Negative Syndrome Scale (PANSS) and the Clinical Global Impression Severity Scale (CGI-S). Physical and neurological examinations were performed in each of the patients and controls. RESULTS: Nucleosome, total oxidant levels and OSI values were higher in schizophrenia patients than in controls (p < 0.05). There was no signifi cant difference in the total antioxidant levels. There was a positive correlation between the nucleosome level and PANSS positive subscale (p = 0.028, r = 0.402). There was a positive correlation between TAS and age (p = 0.025, r = 0.289), PANSS total (p < 0.001, r = 0.604). There was a negative correlation between OSI and PANSS total (p = 0.019, r = -0.427), PANSS positive subscale (p = 0.043, r = -0.372). There was a negative correlation between TOS and PANS total (p = 0.028, r = -0.402). CONCLUSION: In this study we found a correlation between nucleosome level and PANSS positive subscale. To our knowledge, this is the fi rst study that evaluates oxidative stress and nucleosomes released from apoptotic cells together (Tab. 2, Ref. 50). Text in PDF www.elis.sk.

Aim:In this study, we aim to investigate whether any the correlation exists between 25-hidroxy vitamin D (vitamin D) and platelet indices in childhood. Methods:We planned a retrospective study. Firstly, we scanned vitamin D and hemogram tests of children, who consulted to pediatric clinic with any simple complaint from January 2014 to December 2016. We finally included 346 children (168 female and 178 male) aged 0-18 years in order to evaluate the correlation between vitamin D, and platelet indices.Results: Significant differences were not observed between the average ages of the study groups (p=0.856) as well as sex (p=0.907). We did not determine any significant difference among seasons in terms of vitamin D level (p=0.512). Finally, we did not also found any correlation between vitamin D level and platelet indices in all groups (p>0.05). Conclusion:Vitamin D level was not related to platelet indices in healthy children. On the other hand, we consider that there is a need further studies to validate our findings. Sonuç: Sağlıklı çocuklarda vitamin D düzeyi trombosit indeksleri ile ilişkili değildi. Bununla birlikte, bulgularımızı doğrulayacak daha ileri çalışmalara ihtiyaç olduğu düşüncesindeyiz.

Introduction:We aimed to investigate the impact of serum zinc, and vitamin D levels on the development of asthma, and its clinical characteristics.Methods:In our cross-sectional study; 50 patients who were diagnosed as atopic asthma and 70 healthy children consisted the control group. In both groups levels of vitamin D, and zinc were analyzed.Results:A statistically significant intergroup difference was not detected as for age, gender, body height (percentile), and weight (percentile) of the patients (p>0.05). Mean vitamin D levels in the asthmatic patient, and control groups were 32.61±9.48 nmol/L, and 42.55±15.42 nmol/L, respectively. Between two groups a statistically significant difference was found (p=0.001). Zinc levels were higher in the control group without any statistically significant difference between groups (p=0.25). A statistically significant negative correlation (−0.635) was found between vitamin D levels, and severity of asthma in the patient group. As the level of vitamin D increased, a decrease in severity of asthma was seen (p=0.04).Conclusion:Though larger series are needed to arrive at definitive conclusions, we think that vitamin D deficiency rather than zinc deficiency, might convey importance in the emergence, and exacerbation of asthma.

No abstract

Objectives Diagnosis of pediatric patients presenting to the Emergency Department with acute abdominal pain is not always easy. The purpose of this study was to investigate the effectiveness of irisin, a peptide hormone with reactivity shown in the appendix and neutrophils, in the differential diagnosis of pediatric patients with acute abdominal pain. Methods 162 subjects consenting to participate, including 112 patients presenting to the Pediatric Emergency and Pediatric Surgery clinics with acute abdominal pain and 50 controls, were enrolled in the study. Blood was collected from all patients following initial examination for irisin, WBC, and CRP investigation. Results Mean irisin levels in cases of acute appendicitis (AA) and perforated appendicitis (PA) were statistically significantly higher compared to nonspecific abdominal pains and the control group. No statistically significant difference was observed in irisin levels between AA and PA cases. WBC and CRP levels were also significantly higher in cases of AA and PA compared to nonspecific abdominal pains. Conclusions Differential diagnosis of acute abdominal pains in children and deciding on surgery are a difficult and complex process. Our study shows that irisin can be a useful biomarker in differentiating AA and PA from other acute abdominal pains in children.

Methods:- Results:was 8.8% (n = 48). Key words:J Pediatr Emerg Intens Care Med 2015; 2: 65-70 BULGULARÜnitemizde 2007 -2013 tarihleri arasında takip ve tedavi edilen toplam 546 hastanın 283'ü erkek (%52), 263'ü kız (%48) idi. Hastalarımızda ortanca yaş 24 ay; yaş dağılım aralığı 1 -240 ay, yatış günü ortanca değeri 3 gün; yatış günü dağılım aralığı 1 -430 gün olarak tespit edildi.Çalışma süresince ünitemize yatırılan hasta sayısının aynı dönemde hastanemizde yatan hasta sayısının %1.4'ü olduğu görüldü. Hastalarımızın %78'i çocuk acilden, %17'si çocuk kliniği servislerinden, %5'i ise dış merkezlerden ünitemize kabul edilmişti.Hastaların yatış tanıları incelendiğinde ilk üç sırada solunum sistemi hastalıkları (n=314, %57,5), nörolojik hastalıklar (n=225,%41,2) ve zehirlenmeler (n=96,%17,6) yer alıyordu. 442 (%80,9) hastanın yatış nedeni olan birden fazla tanısı vardı. Yatış nedenleri ve görülme sıklık-ları Tablo 1'de verilmiştir. Diğer hastalıklar başlığı içinde travma, romatolojik hastalıklar, gastrointestinal sistem hastalıkları, onkolojik hastalıklar, allerjik hastalıklar, dermatolojik hastalıklar, göz hastalıkları, çocuk cerrahisinin postoperatif hastaları yer alıyordu.Çalışmaya aldığımız hastaların %41,1'inde (n=226) yoğun bakım yatışları esnasında eşlik eden kronik hastalık tespit edildi. Mevcut kronik hastalıklar sıklık sırasına göre nörolojik sistem hastalıkları (n=124, %22,7), kardiyovasküler sistem hastalıkları (n=39, %7,1) ve metabolik sistem hastalıkları (n=30, %5.3) şeklindeydi (Tablo 2).Hastaların 133'ünde (%24,4) MV gereksinimi oldu. Hastaların MV'de kalış süresi ortanca değeri 120 saat (1 saat-2160 saat) olarak saptandı. Mekanik ventilatör desteği alan hastaların 46'sı (%34,6) kaybedildi. Hastaların 19'u (%3,5) trakeostomili idi. Trakeostomili hastalarımızın 13'üne ünitemizde yatarken trakeostomi açılmış, 6'sının ise yatışlarında trakeostomileri vardı.Kan ve kan ürünleri transfüzyonu yapılan hasta sayısı 117 (%21,4) olarak tespit edildi. Hastaların 57'sine (%10,4) eritrosit süspansiyonu (ES) ve taze donmuş plazma (TDP), 38'ine (%7) ES, 18'ine (%3,3) TDP, 4'üne (%0,7) ES-TDP-trombosit süspansiyonu (TS), 2'sine (%0,4) intravenöz immünglobulin transfüzyonu yapıldı. Kan ve kan ürünleri transfüzyonu yapılan hastaların 35'i (%29,9) eks oldu.Çocuk yoğun bakım gereksinimi ortadan kalkan 316 (%57,9) hastanın takip ve tedavilerinin devamı için diğer bir servise yatışı yapıldı. Hastaların 84'ü (%15,4) ise kardiyak cerrahi, renal replasman tedavisi, plazma değişimi, bronkoskopi ihtiyacı nedeni ile düzey 3 hizmet veren ço-cuk yoğun bakım ünitelerine sevk edildi. Hastaların 98'i (%17,9) direkt çocuk yoğun bakımımızdan taburcu edildi. Yoğun bakımda takip ettiğimiz hastalarda kaba mortalite

Aim: Breastfeeding ensures ideal physical, intellectual and behavioral development of infants, and also protects them against infections and chronic diseases. In this study, we aimed to evaluate the impact of feeding patterns on physical growth and mental development of infants in the first 6 months of life.Methods:In this study, we retrospectively analyzed medical files of infants aged between 0 and 6 months who were referred to a provincial family health center. According to their feeding patterns, they were divided into 3 groups as only breastfed group (group AS, n=63), only formula-fed group (group FM, n=30), and the group of infants fed with both breast milk, and baby formulas (group AF, n=63). Weight, height and head circumferences of the infants were measured at birth, and at postnatal months 1., 2., 3., 4., and 6. and were evaluated for each group.Results: Normal birth rate was higher in the breastfed group (41.3%) when compared with the formula-fed babies (31.6%). During 6 weeks of the follow-up period, statistically significant increases were detected in body weights of the infants fed only with breast milk at months 1., 2. and 3., in body heights at month 2, and in head circumferences at months 1., 2. and 3. (p<0.05). The increase in body height in the infants fed both with breast milk and baby formulas was higher at months 4, and 6 than those in the other groups.Conclusion:Breast-fed babies grow faster than formula-fed babies within the first months of life, but later on, their growth rates slow down. However, they grow up with a healthier life and mental capabilities as well as being protected from deleterious effects of obesity. (The Me di cal Bul le tin of Ha se ki 2015; 53:199-203)