The Diagnostic Value of Irisin in Pediatric Patients with Acute Abdominal Pain

Saraç, Fatma; Sarsu, Sevgi Büyükbeşe; Yeniocak, Selman; Şahin, Kamil; Yücetaş, Esma; Dogan, Yildirim; Koldaş, Macit; Uzun, Özlem Ünal

doi:10.1155/2018/3296535

Cited by 6 publications

(4 citation statements)

References 20 publications

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“…The authors attributed the observed positive correlation between irisin and proinflammatory cytokines to a compensatory increase of irisin to limit lipid accumulation and inflammatory changes in the liver of children at increased risk of NAFLD. In another study conducted by Sarac et al, higher levels of irisin as well as of hs-CRP were found in children with acute appendicitis compared with controls [76]. This finding might suggest that irisin secretion increases in conditions characterized by a state of inflammation.…”

Section: Discussionmentioning

confidence: 96%

Association between Irisin, hs-CRP, and Metabolic Status in Children and Adolescents with Type 2 Diabetes Mellitus

Elizondo‐Montemayor

Gonzalez‐Gil

Tamez-Rivera

et al. 2019

Mediators of Inflammation

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Proinflammatory cytokines and the novel myokine irisin, a cleavage product of FNDC5, have been found to play a role in obesity and type 2 diabetes mellitus (T2DM). Irisin has been shown to increase browning of adipose tissue, thermogenesis, energy expenditure, and insulin sensitivity, yet its association with inflammatory markers is still limited. Circulating irisin has been found to be increased in obesity, while in adult subjects with T2DM decreased levels have been found. However, data establishing the association of circulating irisin in children and adolescents with T2DM has not been described in the literature. The objective of this study was to determine irisin plasma concentration and its association with metabolic and adiposity markers and with hs-CRP, a surrogate marker of inflammation used in clinical practice, in a pediatric population with T2DM. A cross-sample of 40 Mexican children and adolescents aged 7-17 were recruited, 20 diagnosed with T2DM and 20 healthy controls. Plasma irisin levels were found to be lower in the T2DM group compared with controls, which could be attributed to a reduced PGC-1α activity in muscle tissue with a consequent decrease in FNDC5 and irisin expression. Irisin concentration was found to be positively correlated with HDL-c, LDL-c, and total cholesterol, while negatively correlated with BMI, waist circumference, and triglycerides. However, after multiple regression analysis, only HDL-c correlation remained significant. hs-CRP was higher in the T2DM group and positively associated with adiposity markers, unfavorable lipid profile, insulin levels, and HOMA-IR, but no association with irisin was found. Given the favorable metabolic effects attributed to irisin, the low plasma levels found in children and adolescents with T2DM could exacerbate the inflammatory and metabolic imbalances and the intrinsic cardiovascular risk of this disease. We propose an “irisin-proinflammatory/anti-inflammatory axis” to explain the role of irisin as a metabolic regulator in obesity and T2DM.

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Section: Discussionmentioning

confidence: 96%

Association between Irisin, hs-CRP, and Metabolic Status in Children and Adolescents with Type 2 Diabetes Mellitus

Elizondo‐Montemayor

Gonzalez‐Gil

Tamez-Rivera

et al. 2019

Mediators of Inflammation

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“…Finally, irisin, an exercise hormone that is derived from skeletal muscle, has recently been confirmed to have activity within the appendix [64]. Increased blood irisin levels have been shown in patients with acute and perforated appendicitis compared with patients with nonspecific abdominal pain [35]. Though further studies are needed, these preliminary findings suggest that irisin may be a useful biomarker in differentiating acute appendicitis from other causes of acute abdominal pain in children [35,64].…”

Section: Novel Protein Biomarkersmentioning

confidence: 88%

Novel Molecular Biomarkers and Diagnosis of Acute Appendicitis in Children

et al. 2021

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Reliable and efficient diagnosis of pediatric appendicitis is essential for the establishment of a clinical management plan and improvement of patient outcomes. Current strategies used to diagnose a child presenting with a suspected appendicitis include laboratory studies, clinical scores and diagnostic imaging. Although these modalities work in conjunction with each other, one optimal diagnostic strategy has yet to be agreed upon. The recent introduction of precision medicine techniques such as genomics, transcriptomics, proteomics and metabolomics has increased both the diagnostic sensitivity and specificity of appendicitis. Using these novel strategies, the integration of precision medicine into clinical practice via point-of-care technologies is a plausible future. These technologies would assist in the screening, diagnosis and prognosis of pediatric appendicitis.

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“…Occlusion of capillaries and venules and finally venous ischemia develop following increased intraluminal pressure with obstruction of the lumen and associated lumen secretions developing in AA. Arterial ischemia finally occurs, and necrosis and perforation result [23,24]. IMA levels rise as a result of this ischemia.…”

Section: Discussionmentioning

confidence: 99%

The Diagnostic Values of Ischemia-Modified Albumin in Patients with Acute Abdominal Pain and Its Role in Differentiating Acute Abdomen

Yeniocak

Saraç

Yazıcıoğlu

et al. 2020

Emergency Medicine International

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Aim. The aim of this study was to evaluate the diagnostic value of serum ischemia-modified albumin (IMA) levels in patients presenting to the emergency department with acute abdominal pain and its use in differentiating acute surgical abdomen. Methods. This single-center prospective cross-sectional study included 334 adult patients who presented to the emergency department. These consisted of 194 patients (Group 1) with nontraumatic abdominal pain commencing in the preceding week, who were definitely diagnosed and either hospitalized in a specific department or planned for discharge, and a control group of 140 patients (Group 2). Results. The mean IMA value of the patients diagnosed with acute appendicitis was statistically significantly higher than that of the control group. The mean IMA value of the patients diagnosed with acute appendicitis, ovarian pathologies, and gastritis-peptic ulcer was statistically significantly higher than that of the nonspecific abdominal pain group. Conclusion. Serum IMA levels can be used as a diagnostic marker in patients with acute appendicitis. Furthermore, serum IMA levels in patients presenting to the emergency department with abdominal pain may be indicative of patients requiring surgery or of complicated cases, particularly in terms of acute appendicitis and ovarian pathologies.

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The Diagnostic Value of Irisin in Pediatric Patients with Acute Abdominal Pain

Cited by 6 publications

References 20 publications

Association between Irisin, hs-CRP, and Metabolic Status in Children and Adolescents with Type 2 Diabetes Mellitus

Association between Irisin, hs-CRP, and Metabolic Status in Children and Adolescents with Type 2 Diabetes Mellitus

Novel Molecular Biomarkers and Diagnosis of Acute Appendicitis in Children

The Diagnostic Values of Ischemia-Modified Albumin in Patients with Acute Abdominal Pain and Its Role in Differentiating Acute Abdomen

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