The Diagnostic Values of Ischemia-Modified Albumin in Patients with Acute Abdominal Pain and Its Role in Differentiating Acute Abdomen

Yeniocak, Selman; Saraç, Fatma; Yazıcıoğlu, Mustafa Ömer; Karabulut, Nadiye; Ünal, Akın; Yücetaş, Esma; Koldaş, Macit; Akkoç, İbrahim; Ekici, Mustafa Ayhan; Evrın, Togay

doi:10.1155/2020/7925975

Cited by 3 publications

(1 citation statement)

References 30 publications

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“…When binding of transition metals (copper, cobalt and nickel) to the N-terminal of Albumin is reduced in hypoxia or acidosis, it is called ischemia modified albumin (IMAL). I-FABP, D-lactate, alpha-GST and IMAL have been shown to be elevated in early AMI[ 61 - 63 ] but at the present time they are not being used in our clinical practice.…”

Section: Isbodi In 2021mentioning

confidence: 99%

Ischemic bowel disease in 2021

Ahmed¹

2021

WJG

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Ischemic bowel disease (ISBODI) includes colon ischemia, acute mesenteric ischemia (AMI) and chronic mesenteric ischemia (CMI). Epidemiologically, colon ischemia is the most common type followed by AMI and CMI. There are various risk factors for the development of ISBODI. Abdominal pain is the common presenting symptom of each type. High clinical suspicion is essential in ordering appropriate tests. Imaging studies and colonoscopy with biopsy are the main diagnostic tests. Treatment varies from conservative measures to surgical resection and revascularization. Involvement of multidisciplinary team is essential in managing ISBODI. Although open surgery with revascularization plays an important role, recently there is an increasing interest in percutaneous endovascular treatment.

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Section: Isbodi In 2021mentioning

confidence: 99%

Ischemic bowel disease in 2021

Ahmed¹

2021

WJG

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Utility of Ischemia-Modified Albumin as a Biomarker for Acute Appendicitis: A Systematic Review and Meta-Analysis

Singh,

Pogorelić,

Agrawal

et al. 2023

JCM

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Background: Acute appendicitis is a frequently encountered surgical emergency. Despite several scoring systems, the possibility of delayed diagnosis persists. In addition, a delayed diagnosis leads to an increased risk of complicated appendicitis. Hence, there is a need to identify biological markers to help clinicians rapidly and accurately diagnose and prognosticate acute appendicitis with a high sensitivity and specificity. Although several markers have been evaluated, the pressing concern is still the low specificity of these markers. One such marker is serum ischemia-modified albumin (IMA), which can be a novel biomarker for accurately diagnosing and prognosticating acute appendicitis. Methods: The authors conducted a systematic search of the PubMed, EMBASE, Web of Science, and Scopus databases through February 2023 as per the PRISMA guidelines. The difference in the levels of IMA between patients with acute appendicitis vs. healthy controls, and the difference in the levels of IMA between patients with complicated vs. non-complicated acute appendicitis were taken as the outcome measures. Statistical analysis was performed using a random effects model and mean difference (MD) was calculated. The methodological quality of the studies was assessed by utilizing the Newcastle–Ottawa scale. Results: A total of six prospective comparative studies were included in the meta-analysis. The analysis revealed that the mean level of serum IMA was significantly raised in the acute appendicitis group (MD 0.21, 95% CI 0.05 to 0.37, p = 0.01). Similarly, the mean serum IMA levels were also raised in the complicated appendicitis group compared to the non-complicated appendicitis group (MD 0.05, 95% CI 0.01 to 0.10, p = 0.02). Three of the studies included were, however, of poor methodological quality. Conclusions: Serum IMA is a viable potential marker for diagnosing and prognosticating acute appendicitis. However, due to the limited methodological quality of available studies, further prospectively designed and adequately powered studies are needed.

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The role of thiol-disulfide and ischemia-modified albumin levels in the diagnosis of childhood appendicitis

Ertürk¹,

Öztorun

Bostancı

et al. 2021

Anatolian Current Medical Journal

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Aim:The accurate diagnosis of acute appendicitis can be achieved by a combination of evaluation of clinical symptoms, physical examination findings and history taking, but is still challenging for the clinician. Some biochemical markers have been evaluated for the purpose of increasing the diagnostic accuracy rate for appendicitis. In this study, our aim is to evaluate the diagnostic value of thiol-disulfide levels and IMA, in pediatric patients with suspected acute appendicitis. Material And Method:The children (1-17 years age) who were admitted to our clinic for suspected acute appendicitis between March 2017 and September 2017 were evaluated. A total of 238 children are enrolled in the study; 119 were operated for suspected acute appendicitis and the 119 children who did not have appendicitis constituted the control group. Serum levels of native thiol (-SH), total thiol (SH+SS), dynamic disulfide (SS), dynamic disulfide (SS)/total thiol (SH+SS) ratio, albumin, ischemic modified albumin (IMA) and WBC levels were obtained and compared within groups. Results:The mean age of the patients was 10.9 years (±3.7, 3-17 years) and 9.1 years (±3.7, 1-17 years) in the operation and the control groups, respectively. The SH, SH+SS, SS and albumin levels and SS/SH+SS ratio were significantly lower and IMA levels were significantly higher in the operation group than the control group. Among the operated patients, IMA and dynamic disulfide levels were significantly higher and WBC levels were significantly lower in patients with non-perforated appendicitis than patients with perforated appendicitis. A significant decrease in serum levels of IMA was observed in the postoperative 1st day when compared with the preoperative values. Conclusion:Measuring the IMA levels with thiol/disulfide homeostasis may increase the diagnostic accuracy rate when evaluating the patients with suspected appendicitis. However, it appears that these evaluations fail to distinguish the patients with perforated and non-perforated appendicitis, thus further studies are necessary.

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The Diagnostic Values of Ischemia-Modified Albumin in Patients with Acute Abdominal Pain and Its Role in Differentiating Acute Abdomen

Cited by 3 publications

References 30 publications

Ischemic bowel disease in 2021

Ischemic bowel disease in 2021

Utility of Ischemia-Modified Albumin as a Biomarker for Acute Appendicitis: A Systematic Review and Meta-Analysis

The role of thiol-disulfide and ischemia-modified albumin levels in the diagnosis of childhood appendicitis

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