Correlation Between Vitamin D Level and Platelet Indices in Children Aged 0-18 Years

Coşkun, Cihan; Şahin, Kamil

doi:10.4274/haseki.41736

Cited by 7 publications

(6 citation statements)

References 18 publications

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“…Others showed that when a body exposed to overdose vitamin D, hemopoietic organ produce more blood cells and thus, the PCV level growing gradually (Meguro et al, 2011). As well Coşkun and Şahin (2018) observed that there was no difference between 25(OH)D in concentrations less than 20, 20-32, more than 32 ng/ml in PLT, also PDW was higher at female in healthy children aged 0-18 years. Table 3 has shown a signi icant decrease in ALT, a signi icant increase in AST compared with the control after 20, and 30 days of the dosing also TP indicate signi icant decrease after 30 days only whereas milk and albumin groups did not show any signi icant differences as compared with the control.…”

Section: Results Ofmentioning

confidence: 95%

Effect of Hypervitaminosis D3 on Liver, Kidney Functions in White Rats

Al-Hayali

2020

ijrps

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The research was undertaken to evaluate the effects of vitamin D3 on the liver and kidney functions through some haematological and biochemical parameters. The results illustrate that high doses (30000 and 50000 IU) of vitamin D3 significantly reduce the rats' body weights in about 46% additionally much of symptoms like weakness, the rigidity of limbs, neurological irritation, difficulty in movement, respiration and deaths occurrence. The results also showed that the high doses vitamin D3 has a significant decreased in Red Blood Corpuscles (RBCs), Hemoglobin (Hb), Packed Cell Volume (PCV), Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), White Blood Corpuscles (WBCs), Lymphocytes (Lymph), Monocytes (Mono), Granulocytes (GRA) and Platelets (PLT) compared with the control group. In contrast, the Mean Corpuscular Hemoglobin Concentration (MCHC) and Platelet Distribution Width (PDW) significantly increased after 20-30 days of treatment . Besides, the results demonstrated a significant decrease in Alanine aminotransferase (ALT), Total Protein (TP), Creatinine (Cr) and increase in aspartate aminotransferase (AST), Blood Urea Nitrogen (BUN), Urea. While albumin did not give any significant differences. As well the study proved significantly increase in serum vitamin D3 concentration compared with the control group after 20-30 days of treatment. Since vitamin D3 can be beneficial for the organisms, but the overdoses of the vitamin can alter some parameters in the body.

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Section: Results Ofmentioning

confidence: 95%

Effect of Hypervitaminosis D3 on Liver, Kidney Functions in White Rats

Al-Hayali

2020

ijrps

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“…[1] In recent studies conducted in Turkey, the prevalence of vitamin D deficiency has been reported from 16.5% to 89.6% (Table 4). [6][7][8][9][10][11][12][13][14][15][16][17] Among these studies, the highest rate of vitamin D deficiency was found in the study included pubertal children and adolescents. [11] The lowest deficiency rate was shown in a study conducted on children younger than 10 years old.…”

Section: Discussionmentioning

confidence: 99%

“…[15] However, the studies with all pediatric age groups reported that vitamin D deficiency was in the range of 35.1% to 65.0%. [7,8,13,14,16,17] In a study with more than ninety thousand participants, Sahin et al [6] found that vitamin D deficiency was 45-50% in children younger than 10 and 80-90% older than 10. The results of this study were significant due to the high number of participants.…”

Section: Discussionmentioning

confidence: 99%

“…[2] Similarly, vitamin D deficiency was commonly reported in studies conducted in different regions of Turkey. [6][7][8][9][10] In most studies, vitamin D deficiency prevalence estimates vary due to deficiency definitions, assessed areas, and considered risk factors. Primary causes of vitamin D deficiency are inadequate vitamin D intake by nutrition and insufficient sunlight exposure.…”

Section: Introductionmentioning

confidence: 99%

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Frequency of Vitamin D Deficiency in Children: A Single-Center Cross-Sectional Study in Istanbul

Varkal¹,

Özçetin²,

Kılıç³

2021

Journal of Contemporary Medicine

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Aim: Vitamin D deficiency is highly prevalent among children worldwide. This study aims to assess the frequency of vitamin D deficiency in children and how it varies according to gender, age, and season in Istanbul. Material and Method:The study included 3096 children aged 0-18 admitted to the pediatric outpatient clinic in Istanbul. The serum 25 hydroxyvitamin D concentration was analyzed by the High-Performance Liquid Chromatography method using HPLC systems analyzers, and the results were categorized into four groups: deficiency (<20 ng/mL), insufficiency (20-30 ng/mL), sufficiency (30-100 ng/mL), and toxicity (>100 ng/mL). Descriptive methods, Chi-square, Independent Samples T-Test, ANOVA, and correlation test were used in the statistical analysis of the data.Results: Of children, 52% were girls and 48% boys. The mean serum 25 hydroxyvitamin D concentration was 21.8±15.8 ng/mL, and the frequency of vitamin D deficiency was 53.1%. There was a different distribution of vitamin D status between age groups. Vitamin D deficiency was more common in older children. The frequency of vitamin D deficiency was significantly higher in girls than boys (57.6% versus 48.3%). The mean serum 25 hydroxyvitamin D concentration was significantly lower in winter and spring. A moderate negative correlation was found between age and serum 25 hydroxyvitamin D concentration (correlation coefficient:-0.36). Conclusion:This study showed that female sex, older children, and the winter/spring seasons were significantly associated with a higher frequency of vitamin D deficiency and a lower mean serum 25 hydroxyvitamin D concentration.

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“…platelets with a smaller size, larger platelets have more granules, are more aggregative in nature, possess a higher concentration of thromboxane A2, and express more glycoprotein Ib and IIb/IIIa receptors [6]. In addition, platelet indices also consist of plateletcrit (PCT) which refers to a ratio between platelet volume and whole blood volume as well as platelet distribution width (PDW) which determines the distribution of particle size in platelets [7].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D and Hemostasis Parameters in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome Patients with Pulmonary Tuberculosis Coinfections

Erica

Sari

Siregar

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS) remains one of the most common causes of Vitamin D deficiency and homeostasis disorders due to its progressiveness and complications. AIM: This study aims to determine the relationship of Vitamin D levels with hemostasis in HIV/AIDS patients with and without pulmonary tuberculosis (TB), who were consuming efavirenz (EFV)-based antiretroviral therapy (ART) for <6 months, with or without rifampicin-based antituberculosis treatment. METHODS: 25(OH)D concentration, prothrombin time (PT), and platelet index were measured in HIV/AIDS patients with and without pulmonary TB, who were consuming EFV-based ART for <6 months, with or without rifampicin-based antituberculosis treatment. This study was conducted in the Special Treatment Centers (Pusat Pelayanan Khusus, Pusyansus) Voluntary Counseling and Testing clinic at Rumah Sakit Umum Pusat (RSUP) Haji Adam Malik, Medan, Indonesia, between August and October 2019. RESULTS: We found no significant difference in terms of 25(OH)D concentration, PT, and platelet index between the two groups, except for platelet distribution width (PDW) differs significantly between HIV/AIDS-pulmonary TB group and HIV/AIDS only group (p = 0.026). We observed a significant difference in terms of mean platelet volume and PDW between baseline and after treatment for <6 months (p ≤ 0.05) in the HIV/AIDS-pulmonary TB group and in the HIV/AIDS only group. A significant difference was also observed in terms of platelet count (p = 0.021) before and after EFV-based ART for <6 months p ≤ 0.05) in the HIV/AIDS-pulmonary TB group. CONCLUSION: There is no correlation between 25(OH)D concentration and PT or platelet index in HIV/AIDS patients with and without pulmonary TB who were consuming EFV-based ART- and rifampicin-based antituberculosis for <6 months.

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Correlation Between Vitamin D Level and Platelet Indices in Children Aged 0-18 Years

Cited by 7 publications

References 18 publications

Effect of Hypervitaminosis D3 on Liver, Kidney Functions in White Rats

Effect of Hypervitaminosis D3 on Liver, Kidney Functions in White Rats

Frequency of Vitamin D Deficiency in Children: A Single-Center Cross-Sectional Study in Istanbul

Vitamin D and Hemostasis Parameters in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome Patients with Pulmonary Tuberculosis Coinfections

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