The objective of this clinical study was to compare conventional caries detection techniques, pen-type laser fluorescence device, and near-infrared light transillumination method in approximal dentin caries lesions. The study included 157 patients, aged 12-18, without any cavity in the posterior teeth. Two calibrated examiners carried out the assessments of selected approximal caries sites independently. After the assessments, the unopened sites were excluded and a total of 161 approximal sites were included in the study. When both the examiners arrived at a consensus regarding the presence of dentin caries, the detected lesions were opened with a conical diamond burr, the cavity extent was examined and validated (gold standard). Sensitivity, specificity, negative predictive value, positive predictive value, accuracy, and area under the ROC curve (Az) values among the caries detection methods were calculated. Bitewing radiography and near-infrared (NIR) light transillumination methods showed the highest sensitivity (0.83-0.82) and accuracy (0.82-0.80) among the methods. Visual inspection showed the lowest sensitivity (0.54). Laser fluorescence device and visual inspection showed nearly equal performance. Near-infrared light transillumination can be used as an alternative method to approximal dentin caries detection. Visual inspection and laser fluorescence device alone should not be used for approximal dentin caries.

Oral Aspects in Children with Nephrotic Syndrome A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Nephrotic syndrome (NS) is caused by different disorders that damage the kidneys. This damage leads to the excessive release of protein into the urine. Due to alterations in mineral metabolism in young patients with nephrotic syndrome, dental development, periodontal tissues, and alveolar bone may be disturbed. The aim of this study was to assess the oral health status in children with nephrotic syndrome and compare the results with a control group. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : The study was carried out at the

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Objective: Dental caries is an important public health issue worldwide. In developing countries preventive dentistry is not common; hence, oral and dental health problems continue to generate serious economic and social issues. The aim of this study was to assess oral health and the incidence of dental caries in systemically healthy children aged 3-14 years, provide education on oral hygiene motivation, conduct the necessary preventive and restorative procedures, and reassess caries development at the 6-, 12-, and 18-month post-treatment follow-up. Methods: Systemically healthy children aged 3-14 years who applied to the Paediatric Dentistry Clinic, Faculty of Dentistry, Adnan Menderes University (ADU) were included in the study. The subjects were evaluated for oral health status and incidence of dental caries based on surveys and clinical examination, motivation for oral hygiene with necessary training, completion of preventive and restorative treatments, and development of dental caries at the 6-, 12-, and 18-month post-treatment follow-up. Results: The study included 320 patients, aged 3-14 years (mean age 8.08 ± 3.45 years). In children included in the study, the average decayed (d), missing (m) and filled (f) primary teeth (dmft) value was 3.81 (min-max: 0-16), decayed (D), missing (M) and filled (F) permanent teeth (DMFT) value, 1.49 (min-max: 0-6), decayed (d), missing(m) and filled(f) primary teeth surface (dmfs) value, 10.11 (min-max: 0-40), and decayed (D), missing (M) and filled (F) permanent teeth surface (DMFS) value, 2.09 (min-max: 0-12). Conclusions: For the protection and maintenance of oral and dental health in dentistry, preventive approaches should be the first concern and conservative therapeutic methods should be given priority after occurrence of any dental pathology. In addition, one-time examinations are not sufficient, and children should be examined at least twice a year. This study showed that the incidence of dental caries declined in children who underwent periodical examination and preventive dental treatment.

The protective role of selenium against dental amalgam-induced intracellular oxidative toxicity through the TRPV1 channel in DBTRG glioblastoma cells Objective: The exposure to mercury (Hg) from dental amalgams is a suspected causative factor in neurological diseases. This study investigated the toxic effects of two different amalgam compositions related to Hg and the protective effects of selenium against the toxic effects of Hg through the TRPV1 channel in the human DBTRG glioblastoma cell line. Methodology: Six groups of the cells were organized. Analyses of cell viability, apoptosis, caspase 3 and caspase 9 activities, mitochondrial membrane depolarization, reactive oxygen species (ROS) production, and Western Blotting for protein expression levels were performed. Results: Cell viability values were lower in amalgam with high copper (HCu) and low copper (LCu) groups independently of time but were increased by selenium and capsazepine (p<0.001 and p<0.05). Conversely, apoptosis rates, caspase 3 and caspase 9 expression, ROS formation, mitochondrial membrane depolarization, and protein expression levels were higher in the HCu and LCu groups but were decreased by selenium (p<0.001 and p<0.05). Conclusions: Selenium combined with an amalgam of either HCu or LCu decreases the toxic effects created by Hg in human DBTRG glioblastoma cells.

Objective: Various instruments can be used in children to determine the impact of Oral Health Related Quality of Life (OHRQoL). Child Perceptions Questionnaire (CPQ 8-10) can be used to evaluate the oral symptoms, functional limitations, emotional well-being and social well-being of subjects. Our study aimed at evaluating the impact of dental caries on OHRQoL and the changes in quality of life of subjects after treatment of dental caries compared to subjects without dental caries using CPQ 8-10. Materials and Methods: Study included a total of 200 systemically healthy subjects aged 8-10 years (110 girls, 90 boys; 9.10±0.8) who referred to Adnan Menderes University Pediatric Dentistry clinic between June 2016 and May 2017. Based on the results of clinical and radiological examination, two groups were created consisting of subjects with (n=100, 9.14±0.81) and without (n=100, 9.05±0.82) dental caries and treatment needs, and CPQ 8-10 questionnaire was used to evaluate the quality of life. Questionnaire was repeated 4 weeks after the completion of treatment of subjects with dental caries. Results were subjected to statistical evaluation. Results: Pre-treatment CPQ 8-10 scores of subjects with dental caries were higher than those of subjects without dental caries (17.46±11.66 and 6.86±4.76, respectively; p<0.001) OHQoL scores were decreased after dental treatment (4.06±5.40) and the difference was statistically significant (p<0.001). CPQ 8-10 scores after dental treatment were lower than those of subjects without dental caries who did not need treatment (p<0.001). Conclusion: We have determined that the untreated dental caries negatively affect the quality of life in children aged 8-10 years, and the quality of life substantially improves after treatment of dental caries. Amaç: Ağız sağlığının yaşam kalitesi üzerine etkisinin Oral Health Related Quality of Life (OHRQoL) belirlenmesi için çocuklarda farklı ölçekler uygulanabilmektedir. "Çocuk Algıları Ölçeği" [Child Perceptions Questionnaire" (CPQ 8-10)] ile gönüllülerin ağız içi semptomları, fonksiyonel kısıtlılıkları, duygusal problemleri ve sosyal etkiler değerlendirilebilmektedir. Çalışmamızda diş çürüğünün OHRQoL üzerine etkisinin değerlendirilmesi, diş çürüklerinin tedavisi sonrasında yaşam kalitesindeki değişimlerinin CPQ 8-10 ile diş çürüğü olmayan gönüllülerle karşılaştırılması amaçlanmıştır.

The number of teeth with fluorosis is increasing, depending on fluorine sources, so more appropriate treatments will need to be evaluated by standardizing the methods employed in related studies.

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