The protective role of selenium against dental amalgam-induced intracellular oxidative toxicity through the TRPV1 channel in DBTRG glioblastoma cells

Ceyhan, Derya; Güzel, Kadriye Görkem Ulu; Çiğ, Bilal

doi:10.1590/1678-7757-2020-0414

Cited by 6 publications

(4 citation statements)

References 37 publications

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“…Espaladori et al found that Se used for intracanal medication could potentiate the healing effects of calcium hydroxide in the anti-inflammatory response in periapical dental tissues [ 45 ]. According to Ceyan et al, Se demonstrated the protective effect against oxidative toxicity induced by dental amalgam [ 46 ].…”

Section: The Role Of Se In the Prevention And Treatment Of Health Dis...mentioning

confidence: 99%

Selenium: An Antioxidant with a Critical Role in Anti-Aging

et al. 2022

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Aging is characterized by an imbalance between damage inflicted by reactive oxygen species (ROS) and the antioxidative defenses of the organism. As a significant nutritional factor, the trace element selenium (Se) may remodel gradual and spontaneous physiological changes caused by oxidative stress, potentially leading to disease prevention and healthy aging. Se is involved in improving antioxidant defense, immune functions, and metabolic homeostasis. An inadequate Se status may reduce human life expectancy by accelerating the aging process or increasing vulnerability to various disorders, including immunity dysfunction, and cancer risk. This review highlights the available studies on the effective role of Se in aging mechanisms and shows the potential clinical implications related to its consumption. The main sources of organic Se and the advantages of its nanoformulations were also discussed.

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Section: The Role Of Se In the Prevention And Treatment Of Health Dis...mentioning

confidence: 99%

Selenium: An Antioxidant with a Critical Role in Anti-Aging

et al. 2022

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“…In central nervous system (CNS) tumors, the cuprotosis-related gene dihydrolipoamide dehydrogenase (DLD) has been demonstrated to induce ferroptosis in head and neck cancer cells by regulating glutamine metabolism [ 12 ]. Copper may inhibit the activity of glioblastoma by impacting the processes of apoptosis and DNA damage repair in glioblastoma cells [ 13 ]. Moreover, copper complexes exhibit anti-tumor cell proliferation effects by modifying the oxidative-reductive state of glioma [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Cuprotosis clusters predict prognosis and immunotherapy response in low-grade glioma

Zhu,

Chen,

et al. 2023

Apoptosis

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Cuprotosis, an emerging mode of cell death, has recently caught the attention of researchers worldwide. However, its impact on low-grade glioma (LGG) patients has not been fully explored. To gain a deeper insight into the relationship between cuprotosis and LGG patients’ prognosis, we conducted this study in which LGG patients were divided into two clusters based on the expression of 18 cuprotosis-related genes. We found that LGG patients in cluster A had better prognosis than those in cluster B. The two clusters also differed in terms of immune cell infiltration and biological functions. Moreover, we identified differentially expressed genes (DEGs) between the two clusters and developed a cuprotosis-related prognostic signature through the least absolute shrinkage and selection operator (LASSO) analysis in the TCGA training cohort. This signature divided LGG patients into high- and low-risk groups, with the high-risk group having significantly shorter overall survival (OS) time than the low-risk group. Its predictive reliability for prognosis in LGG patients was confirmed by the TCGA internal validation cohort, CGGA325 cohort and CGGA693 cohort. Additionally, a nomogram was used to predict the 1-, 3-, and 5-year OS rates of each patient. The analysis of immune checkpoints and tumor mutation burden (TMB) has revealed that individuals belonging to high-risk groups have a greater chance of benefiting from immunotherapy. Functional experiments confirmed that interfering with the signature gene TNFRSF11B inhibited LGG cell proliferation and migration. Overall, this study shed light on the importance of cuprotosis in LGG patient prognosis. The cuprotosis-related prognostic signature is a reliable predictor for patient outcomes and immunotherapeutic response and can help to develop new therapies for LGG.

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“…More importantly, with the con rmation of the speci c mechanism of cuprotosis, the perfect answer to the previous question about why copper inhibits the growth of tumors was given(8). For instance, copper inhibits the activity of glioblastoma cells because cuprotosis may be involved in the development of tumor cells (9). The fact that copper complexes can affect the redox state of gliomas to act as antiproliferative may also be due to the presence of cuprotosis in gliomas (10).…”

Section: Introductionmentioning

confidence: 99%

A Novel Cuprotosis-Related lncRNA Signature Effectively Predicts Prognosis in Glioma Patients

Ballah

Che

et al. 2023

J Mol Neurosci

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Cuprotosis is a novel and different cell death mechanism from the existing known ones that can be used to explore new approaches to treating cancer. Just like ferroptosis and pyroptosis, cuprotosis-related genes regulate various types of tumorigenesis, invasion and metastasis. However, the relationship between cuprotosis related long non-coding RNA (cuprotosis-related lncRNA) in glioma development and prognosis has not been investigated. We obtained relevant data from the Genotype-Tissue Expression (GTEx), Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas (CGGA) and published articles.First, we identi ed 365 cuprotosis-related lncRNAs based on 10 cuprotosis-related differential genes (|R 2 |>0.4, p < 0.001). Then using lasso and Cox regression analysis methods, 12 prognostic cuprotosisrelated lncRNAs were obtained and constructed the CuLncSigi risk score formula. Our next step was to divide the tumor gliomas into two groups (high-risk and low-risk) based on the median risk score, and we found that patients in the high-risk group had a signi cantly worse prognosis. We used internal and external validation methods to simultaneously analyze and validate that the risk score model has good predictive power for patients with glioma. Next, we also performed enrichment analyses such as GSEA and aaGSEA and evaluated the relationship between immune-related drugs and tumor treatment. In conclusion, we successfully constructed a formula of cuprotosis-related lncRNAs with a powerful predictive function. More importantly, our study paves the way for exploring cuprotosis mechanisms in glioma occurrence and development, and helps to nd new relevant biomarkers for glioma early identi cation and diagnosis and to investigate new therapeutic approaches.

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The protective role of selenium against dental amalgam-induced intracellular oxidative toxicity through the TRPV1 channel in DBTRG glioblastoma cells

Cited by 6 publications

References 37 publications

Selenium: An Antioxidant with a Critical Role in Anti-Aging

Selenium: An Antioxidant with a Critical Role in Anti-Aging

Cuprotosis clusters predict prognosis and immunotherapy response in low-grade glioma

A Novel Cuprotosis-Related lncRNA Signature Effectively Predicts Prognosis in Glioma Patients

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