A modification of the distention ulcer was studied in albino rats and a new possibility of testing ulcerogenic side effects of drugs was described. The distention alone was not sufficient to produce lesions. The severity of ulcer lesions was highly dependent on the volume of the acid solution. Large volumes of 0.1 N HC1 evoked severe ulcers within 1 h. Small amounts of weak acid solution did not cause any ulceration. Anti-inflammatory drugs administered in therapeutic doses, which did not yet produce any ulcers in animals, increased the sensitivity of the gastric mucosa against the aggresive factor, the acid. In animals pretreated by anti-inflammatory drugs in toxic doses an earlier development of ulceration was observed by distention with acid. Stress also accelerated and aggravated the formation of distention ulcers.
Chamomile extracts are mainly used because of their antiinflammatory action.Well-known are the antiphlogistic properties of chamazulene and (-)-alpha-bisabolol. So far the effects exerted by bisabolol oxides and by the synthetic racemic compound of bisa-bolo1 have been unclear. Therefore, it was not possible t o determine the relevance of these substances in connection with the standardization of chamomile extracts and preparations.Experiments conducted in rat paw edema (carrageenin) have shown that the antiphlogistic effect exerted by (-)-alpha-bisabolol is considerably more marked than that of the bisabolol oxides A and By and even more pronounced than that of bisabolon oxide and both (+)-alpha-bisabolol and ( + )-alpha-bisabolol.Moreover, that antiphlogistic effect of (-)-alpha-bisabolol could be confirmed in a number of further experimental models, e. g. in adjuvant arthritis of the rat, in UV-erythema of the guinea pig and in yeast fever of the rat. In addition, (-)-alpha-bisabolol reduces the production of mucopolysaccharides in the cell cultures.As was evidenced in the experiments, the content of (-)-alpha-bisabolol is of relevance when assessing the antiphlo-Heruntergeladen von: University of Illinois. Urheberrechtlich geschützt. Literatur Adresse: Dr. 0. Isaac, DaimlerstraJe 25, 0-6000 FrankfurtlM.
Das aus dem Steroidalkohol Hellebrigcnin (I) mit Chloracctylchlorid (II) zugängliche α‐Chloroucctat (III) läßt sich mit dem Dimethylmorpholin (IV) zum Morpholinoacctat (V) umsetzen, mit den Carbonsäurechloriden (VIa) bzw. Anhydridcn (VIa) werden die Ester (VII) erhalten.
Acid secretory effect of pentagastrin and compound 48/80 was studied in the isolated whole stomach of the mouse. Acid secretory response to compound 48/80 was inhibited by cimetidine, indicating histamine involvement in this reaction. Acid secretion stimulated by pentagastrin was not diminished after pre-treatment with compound 48/80 suggesting that gastrin releases non-mast cell histamine. Secretory response to pentagastrin was reduced in Ca++-free serosal media but not to histamine and compound 48/80. A possible pathway of gastrin will be discussed.
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