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Rasamanikya a familiar drug, frequently used by Ayurvedic physicians. It also has a high demand in current pharmaceutical industry. Rasamanikya possesses different pharmaceutical methods with many a proved clinical studies. But it is of utmost importance to understand the safety profile of drug based on assurance which could be done by carrying out animal experimentation. In the present study, Rasamanikya was prepared with three methods. The toxicological study was carried out on acute and sub-acute toxicity of the drug. The three samples when compared together showed that Rasamanikya prepared out of classical Abhraka Patra method and modified Sharava Samputa method showed minimal histopathological changes proving its non-toxicity, whereas Rasamanikya prepared out of electric bulb method showed mild toxicity, but with chances of recovery. Acute toxicity study showed no immediate and evident toxic signs and mortality in histopathology reports and liver function test. However, sub-acute toxicity study showed mild to moderate fatty changes in liver.

Introduction: Mrityunjaya Rasa is a herbo–mineral formulation mentioned under Jwara Chikitsa in Rasendra Sara Sangraha along with different Anupanas. It is having ingredients like Shudha Hingula, Shudha Gandhaka, Shudha Vatsanabha, Shudha Tankana, Pippali and Maricha which show significant result on various types of fever. Aim: To prepare Mrityunjaya Rasa as per guidelines given in classical text book Rasendra Sara Sangraha and to validate physico-chemical analysis of the sample. Methods: The preparation of Mrityunjaya Rasa was carried out at practical hall, Department of Rasashastra and Bhaishajya Kalpana, Shri Dharmasthala Manjunatheshwara College of Ayurveda, Kuthpady, Udupi, Karnataka. It was subjected to analysis on parameters like organoleptic characters, loss on drying, total ash, acid insoluble ash, water soluble ash, pH, alcohol soluble extractive value, and water soluble extractive value. Results: The results of Analytical study showed specific characteristics which are in accordance with the properties of Mrityunjaya Rasa. Conclusion: The study showed significant results, which proves quality of the drugs and efficacy.

Aims: Warm foot bath is a simple, cost-effective, efficient treatment modality used in Naturopathy in the management of hypertension, a preventable and treatable global public health issue. This study was done to assess the effect of warm foot bath on heart rate variability and blood pressure and thereby to substantiate the clinical understanding of its effect in hypertensive individuals. Methodology: From the inpatient department of Shri Dharmasthala Yoga and Nature cure hospital Shantivana, hundred subjects diagnosed with hypertension belonging to the age group of 30 to 60 years were recruited for the study and warm foot bath was given to all the patients. Subjects were assessed for Blood Pressure (BP) and Heart Rate Variability (HRV) before and after the intervention of 15 minutes. Results: The data analysis shows a significant reduction in SBP (p<0.001) and DBP (P<0.001). Result showed there is significant reduction seen in MEAN RR, RMSSD, NN50, PN50, VLF and significant increase in LF, HR, LF/HF ratio p value of (p<0.001). There is no significant change in MEAN HF (p>0.005). Conclusion: The result of the study shows that warm foot bath reduces the sympathetic tone and shifts the Sympatho-vagal balance in favour of parasympathetic dominance and hence, it can be concluded that warm foot bath can be effectively used in the management of hypertension. Trial Registration: Clinical Trial Registry - India (CTRI), CTRI Reg. No.- CTRI/2020/01/022640.

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Abstract:Background and Objectives: Underwater massage has been reported to produce a significant number of physiological changes in blood pressure, heart rate variability, autonomic nervous system, and core temperature in young healthy subjects.

Objective: The present study was designed to find out the acute median lethal dose (LD 50 ) of ammonium sulfate (inorganic fertilizer) in Wister albino rats. Methods:A single dose of ammonium sulfate dissolved in distilled water (Milli-Q) and administered intraperitoneally at concentrations of 10, 30, 50, 70, 90, 110, 130, and 170 mg/kg body weight, respectively, to experimental animals, and then, they were observed every 3 hrs from prior dose given time, later 6 hrs, 12 hrs, 24 hrs, to 48 hrs of noticing any abnormal behaviors and toxic signs, symptoms. After 48 hrs, counted the number of rats departed in each group and mortality percentage was calculated. Results:The obtained results were evaluated by the Statistical Probit Analysis Method and 48 hrs LD 50 value for albino rats was found to be 91.5 mg/kg. At a single dose of 10 mg/kg, there is no morality and toxic behaviors were observed. Therefore, this concentration is considered as no observed adverse effect level dose. Conclusion:From the earlier consequences, identification and evaluation of the LD 50 against ammonium sulfate is crucial for understanding the hyperammonemia because ammonium sulfate has been highly utilized as inorganic fertilizer in agriculture and household gardens. Thus, the knowledge about toxic impacts of ammonia useful for clinical or toxicological approaches; however, the toxicity data are unclear. Hence, the in vitro LD 50 evaluations of target chemical in Wistar rats is highly associated toward in ammonia-related peculiar disorders perceptive and therapy.