Development, Characterization and Antidiabetic Potentials of Nilgirianthusciliatus Nees Derived Nanoparticles

Kavitha, K.; Sujatha, K; Manoharan, Satheesh

doi:10.4172/2155-983x.1000152

Cited by 11 publications

(6 citation statements)

References 43 publications

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“…89 The enhancement in antidiabetic activity of gelatin encapsulated Nilgirianthus ciliatus NPs when compared to the free extracts was ascribed to the sustained release property of these carriers. 90 This result further confirms the benefit of nanoencapsulation in enhancing the biological activity of bioactive agents.…”

Section: Resultssupporting

confidence: 63%

“…In 2017, the in vitro antidiabetic activity of Psoralea corylifolia extract silver NPs was investigated and the results revealed that plant extracts within silver NPs were more effective than that of the free form . The enhancement in antidiabetic activity of gelatin encapsulated Nilgirianthus ciliatus NPs when compared to the free extracts was ascribed to the sustained release property of these carriers . This result further confirms the benefit of nanoencapsulation in enhancing the biological activity of bioactive agents.…”

Section: Resultsmentioning

confidence: 83%

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Poly(ethyl acrylate-co-methyl Methacrylate-co-trimethylammoniethyl methacrylate chloride) (Eudragit RS100) Nanocapsules as Nanovector Carriers for Phoenix dactylifera L. Seeds Oil: a Versatile Antidiabetic Agent

et al. 2020

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Food waste valorization practices have gained considerable attention focusing on the conversion of the waste into valuable products. In this context, the present study provides an insight into a new Eudragit RS100 based nanosystem as a carrier of date palm (Phoenix dactylifera L.) seeds oil known for its an antidiabetic activity. A priori systematic study was carried out in order to understand the individual impact of all contributing factors considered by the nanoprecipitation method. Then, date seeds oil nanoparticles were prepared, characterized and analyzed for their in vitro inhibition activity against: α-amylase and α-glucosidase. The results showed that the developed nanoparticles had an average diameter around 207 nm, a ζ-potential of +59 mV, and an encapsulation efficiency equal to 97 ± 1% with a loading capacity of 0.48 mg•mg −1 . The α-amylase and α-glucosidase IC 50 were found to be 87.6 and 155.3 μg•mL −1 , respectively. Therefore, this study may surely open new perspectives for the development of novel health-promoting plant oils loaded-nanocarriers for several purposes.

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Section: Resultssupporting

confidence: 63%

Section: Resultsmentioning

confidence: 83%

Poly(ethyl acrylate-co-methyl Methacrylate-co-trimethylammoniethyl methacrylate chloride) (Eudragit RS100) Nanocapsules as Nanovector Carriers for Phoenix dactylifera L. Seeds Oil: a Versatile Antidiabetic Agent

et al. 2020

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“…Negligible to no toxicity is crucial for the effective development of a pytotherapeutic preparation [25]. In the current study, the crude extract EEGS and the active fraction of Gymnema sylvestre (TG) were screened for cytotoxicity against 3T3L1 adipose and C2C12 muscle cells at different concentrations.…”

Section: Discussionmentioning

confidence: 99%

A Triterpene Glycoside Fraction, TG from <i>Gymnema sylvestre</i> Ameliorates Insulin Resistance by Stimulating Glucose Uptake in 3T3L1 Adipocytes and C2C12 Skeletal Muscle Cells

Rashmi¹,

Manonmani²

2020

JBM

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“…Diabetes Mellitus (DM) merupakan suatu gangguan yang biasanya ditandai dengan peningkatan kadar gula dalam darah sehingga penyakit ini mempengaruhi sekitar 4% populasi di seluruh dunia (Kavitha et al, 2017) dan 6,9% dari total penduduk Indonesia.…”

Section: Pendahuluanunclassified

Karakterisasi Nanokapsul Ekstrak Daun Serunai (Chromolaena odorata L.) dengan Variasi Kitosan-Alginat Menggunakan Metode Emulsi-Difusi

et al. 2022

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Serunai (Chromolaena odorata L.) is a plant that has been widely used in medicine, one of which is as an antidiabetic. But treatment using plant extracts has drawbacks to the solubility of the active substance and its bioavailability in the body. Nanocapsules are one of the systems in particle technology that can solve this problem by utilizing a polymer that will encapsulate the active substance and release it slowly at the intended target. To achieve this, the manufacture of nanocapsules must meet several characteristic requirements such as particle size, potential zeta, absorption efficiency, and emulsion stability. This study was conducted to identify the nanocapsules characteristics of Serunai leaf extract (Chromolaena odorata L.) with chitosan-alginate variations and identify the influence of chitosan-alginate variations on the characteristics of nanocapsules. This study is a laboratory experimental study with a one-group posttest-only design. The manufacture of Serunai leaf extract nanocapsules using the emulsion-diffusion method, which is then characterized including particle size determination, potential zeta determination, absorption efficiency test (%EE), and emulsion stability test. The results obtained from the determination of the particle size of Formula I 196.4 nm, Formula II 264.2 nm, and Formula III 207.4 nm, potential zeta Formula I -36.1 mV, Formula II -40.1 mV, and Formula III -36.5 mV, the formula I %EE values 99.7%, Formula II 99.8%, and Formula III 99.7%, as well as all formulas indicating the emulsion type m/a. Three formulas have met the requirements of nanocapsules characteristics. The formula is best obtained in Formula II with a chitosan concentration of 0.3% and alginate of 0.6%, so chitosan-alginate variations influence the characteristic results.

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Development, Characterization and Antidiabetic Potentials of Nilgirianthusciliatus Nees Derived Nanoparticles

Cited by 11 publications

References 43 publications

Poly(ethyl acrylate-co-methyl Methacrylate-co-trimethylammoniethyl methacrylate chloride) (Eudragit RS100) Nanocapsules as Nanovector Carriers for Phoenix dactylifera L. Seeds Oil: a Versatile Antidiabetic Agent

Poly(ethyl acrylate-co-methyl Methacrylate-co-trimethylammoniethyl methacrylate chloride) (Eudragit RS100) Nanocapsules as Nanovector Carriers for Phoenix dactylifera L. Seeds Oil: a Versatile Antidiabetic Agent

A Triterpene Glycoside Fraction, TG from <i>Gymnema sylvestre</i> Ameliorates Insulin Resistance by Stimulating Glucose Uptake in 3T3L1 Adipocytes and C2C12 Skeletal Muscle Cells

Karakterisasi Nanokapsul Ekstrak Daun Serunai (Chromolaena odorata L.) dengan Variasi Kitosan-Alginat Menggunakan Metode Emulsi-Difusi

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Development, Characterization and Antidiabetic Potentials of Nilgirianthusciliatus Nees Derived Nanoparticles

Cited by 11 publications

References 43 publications

Poly(ethyl acrylate-co-methyl Methacrylate-co-trimethylammoniethyl methacrylate chloride) (Eudragit RS100) Nanocapsules as Nanovector Carriers for Phoenix dactylifera L. Seeds Oil: a Versatile Antidiabetic Agent

Poly(ethyl acrylate-co-methyl Methacrylate-co-trimethylammoniethyl methacrylate chloride) (Eudragit RS100) Nanocapsules as Nanovector Carriers for Phoenix dactylifera L. Seeds Oil: a Versatile Antidiabetic Agent

A Triterpene Glycoside Fraction, TG from &lt;i&gt;Gymnema sylvestre&lt;/i&gt; Ameliorates Insulin Resistance by Stimulating Glucose Uptake in 3T3L1 Adipocytes and C2C12 Skeletal Muscle Cells

Karakterisasi Nanokapsul Ekstrak Daun Serunai (Chromolaena odorata L.) dengan Variasi Kitosan-Alginat Menggunakan Metode Emulsi-Difusi

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A Triterpene Glycoside Fraction, TG from <i>Gymnema sylvestre</i> Ameliorates Insulin Resistance by Stimulating Glucose Uptake in 3T3L1 Adipocytes and C2C12 Skeletal Muscle Cells