All the ingredients were weighed accurately and dissolved in a suitable solvent with continuous stirring. Then plasticizer was added to the above solution. The resultant solution was stirred for 15 min to get a clear solution and was kept aside for some time to get a bubble free solution, these solutions were casted slowly on a Teflon plate with a continuous flow to avoid bubble formation and the plates were kept at room temperature for 24 hrs. An inverted funnel was placed over the plate to control the rate of drying. (Table1) After 24 hr, formed patch was taken out and checked for its complete dryness. The dried patch was gently separated from the Teflon plate and
B iodegradable interpenetrating polymer network hydrogel membranes of chitosan and gelatin were prepared by solvent casting evaporation method for the controlled release of 5-fluorouracil (5-FU), an anticancer drug. The membranes were characterized by Fourier Transform Infrared Spectroscopy (FTIR), differential scanning calorimeter (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM) and Tensile strength measurements. The FTIR was used to understand the formation of crosslinking and to confirm the absence of chemical interactions between drug and membranes. DSC and XRD studies were performed to understand the crystalline nature of drug after encapsulation into the membranes. SEM was used to study the surface morphology of the membranes. The in vitro studies were carried out in phosphate buffer pH 7.4 at 37°C. The results of controlled release tests showed that the amount of 5-FU release increased with the increasing the amount of gelatin in the membrane. Moreover, the release rate of drug increased as the amount of drug loaded in the membranes increased. All the results indicated that the prepared membrane was potentially useful in drug-delivery systems, and the prolonged release rate was observed up to 12 h.
Niosomes are the non-ionic surfactant vesicles obtained on hydration of synthetic non-ionic surfactants. These are the promising vehicles for effective transdermal drug delivery. The present research work was aimed to develop niosomal-based transdermal Clozapine patch containing a stable formulation with improved drug permeation. Niosomes were prepared by solvent casting method. All the formulations were evaluated for vesicle size, zeta potential and percent entrapment efficiency. All the patches were then characterized for thickness, folding endurance, drug content determination, Flatness, and in vitro permeation studies. F3 formulation having optimum vesicle size (2.6m), highest zeta potential (-32.56mV) and maximum percent entrapment efficiency (98.09%) was selected as optimized formulation. The transdermal patch was prepared using solvent casting method from the optimised niosomes formulation F3 formulation. The prepared optimised niosomes F3 formulation were loaded into the patch formulation. Patches loaded with niosomes (F3NT3) showed 95.78 % cumulative amount of drug permeated. The optimized formulation (F3NT3) followed first order release kinetics.
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