Objective: The aim of the present study was to fabricate and evaluate the drug release studies using Sodium Alginate (SA) and Gelatin (GE) microbeads intercalated with Kaolin (KA) nanoclay for sustained release of D-Penicillamine (D-PA).
Methods: Sodium alginate/gelatin/Kaolin blend microbeads were prepared by an extrusion method by using glutaraldehyde (GA) as a crosslinker. The obtained microbeads were characterized by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and X–ray diffraction (XRD). Drug release kinetics of the microbeads was investigated in simulated intestinal fluid (pH 7.4) at 37 °C.
Results: Microbeads formation was confirmed by FTIR spectroscopy. X-RD reveals that the KA should be intercalated with the drug and also it confirms the molecular level dispersion of D-Penicillamine into microbeads. Scanning Electron Microscopy (SEM) studies reveal that the beads were in spherical shape with some wrinkled depressions on the surface. The in vitro release study indicates the D-Penicillamine released in a controlled manner. The in vitro release kinetics was assessed by Korsmeyer-Peppas equation and the ‘n’ value lies in between 0.557-0.693 indicates Non-Fickian diffusion process.
Conclusion: The results suggest that the developed KA intercalated microbeads are good potential drug carrier for the controlled release of D-PA.
An analysis is carried out to study the coupled heat and mass transfer by mixed convection flow of a Newtonian fluid past a rotating vertical cone embedded in a porous medium in the presence of a magnetic field and chemical reaction effects. The cone surface is maintained at variable temperature and concentration. Similarity transformation is employed to transform the governing partial differential equations into a set of nonlinear ordinary differential equations, which are then solved numerically using shooting method that uses Runge-Kutta and Newton's method. Comparisons with previously published work are performed and results are found to be in excellent agreement. Numerical Results for the velocities, temperature, concentration profiles, as well as local tangential and azimuthal skin friction coefficients, local Nusselt and Sherwood numbers are presented graphically and discussed for different values of the governing parameters to show interesting features of the solutions. This type of study finds significant applications in cooling of electric circuits, packed-bed chemical reactors, solar porous wafer absorber systems, synthesis materials and hygroscopic materials.
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