Formulation and Evaluation of Zidovudine Transdermal Patch using Permeation Enhancers

Mamatha, J.; Gadili, Sravya; Pallavi, K

doi:10.5530/jyp.2020.12s.45

Cited by 8 publications

(4 citation statements)

References 8 publications

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“…Chemical alterations in membrane integrity modify stratum corneum proteins and lipids to promote penetration. (DMSO and oleic acid are an example of the same [30,31]. • Pressure Sensitive Adhesives: The transdermal pharmaceutical provider's pressure-sensitive adhesive (PSA) adheres securely to the body.…”

Section: Components Of Transdermal Drug Delivery Systemmentioning

confidence: 99%

A Simple Glance at the Transdermal Drug Delivery System

Chavan¹,

Shinkar²,

Jadhav³

et al. 2022

Pharmacophore

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The Transdermal Drug Delivery Systems (TDDS), which have evolved as elements of the creation of innovative drug administrative systems, is the most important aspect of pharmaceutical dosage. The use of Transdermal patches has a systemic influence due to the penetration of the drug through the dermis. TDDS is also necessary due to its distinctive benefits. Sustained absorption, more constant plasma concentration, less first-pass metabolism, lower adverse outcomes, quick application, and the mouldability to cease medicines easily by clipping out the skin patches are some of the potential positives of transdermal pharmaceutical delivery. This method of drug delivery has many benefits over conventional oral and intravenous techniques. Ensure the fluid is released in a controlled manner with long-term treatment using drugs. As a result, numerous chemical and physical methods for developing transdermal patches are being investigated. The therapeutic application of first-generation transdermal delivery systems has steadily increased for the administration of tiny, lipophilic, low-dose medicines. Second-generation delivery systems that include chemical enhancers, non-cavitational ultrasound, and iontophoresis regulate administration rates in real-time. Third generation TDDS enhanced permeability of drugs through stratum corneum using microneedle, thermal ablation, microdermabrasion, electroporation and cavitational ultrasound technology. This review article explains how to make different types of transdermal patches. Multiple ways for measuring transdermal dosage and the progression of TDDS were also investigated.

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Section: Components Of Transdermal Drug Delivery Systemmentioning

confidence: 99%

A Simple Glance at the Transdermal Drug Delivery System

Chavan¹,

Shinkar²,

Jadhav³

et al. 2022

Pharmacophore

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show abstract

“…Furthermore, as the DS loading increased from 1.0 to 2.0 (% w/v), the flux value also increased. In theory, lag time (tLag) is the time taken for the drug to be released from the reservoir and become permeable to reach a constant release rate [51][52][53][54]. As referring to Table 2, the lag time for DS-medicated DL A 3C to attain its steady-state was observed to be slight longer than DL B 3C as the nanofiber thickness and DS loading increased, whereas the permeability coefficient (K p ) of DL A 3C was marginally higher (0.035 to 0.022 cm/h) than that of DL B 3C (0.032 to 0.020 cm/h) as the nanofiber thickness and DS loading percentage increased.…”

Section: In Vitro Permeation Studies Of the Diclofenac Sodium (Ds)-medicated Dual Layer Pva Patches Through Cellulose Nitrate Membranementioning

confidence: 99%

Electrospun Nanofiber and Cryogel of Polyvinyl Alcohol Transdermal Patch Containing Diclofenac Sodium: Preparation, Characterization and In Vitro Release Studies

et al. 2021

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Transdermal drug delivery systems (TDDS) have drawn more interest from pharmaceutical scientists because they could provide steady blood levels and prevent the first-pass metabolism over a longer period. Polyvinyl alcohol (PVA) has been widely used in this application due to its biocompatibility, non-toxicity, nanofiber and hydrogel-forming ability. Despite those benefits, their morphology would easily be destroyed by continuous water absorption and contribute to burst drug release due to its hydrophilicity. The aim of this study was to prepare the diclofenac sodium (DS)-medicated dual layer PVA patch using a combination of electrospinning and cryogelation (freeze–thaw) methods to improve the physicochemical properties and drug compatibility and investigate the release of the DS-medicated dual layer PVA patch. Morphological observations using scanning electron microscopy (SEM) verified the polymer−polymer interaction between both layers, whereas Fourier transform infrared (FTIR) spectroscopy has demonstrated the compatibility of DS in PVA matrix up to 2% w/v of PVA volume. The DS loads were found amorphously distributed efficaciously in PVA matrix as no visible spectra of DS–PVA interaction were detected. The DS-medicated dual layer PVA patch with a thicker nanofiber layer (3-milliliter running volume), three freeze–thaw cycles and 2% DS loading labeled as 2%DLB3C show the lowest swelling capacity (18.47%). The in vitro assessment using Franz diffusion cells showed that the 2%DLB3C indicates a better sustained release of DS, with 53.26% of the DS being released after 12 h. The 2%DLB3C owned a flux (Jss) of 0.256 mg/cm2/h and a permeability coefficient (Kp) value of 0.020 cm/h. Thus, the results demonstrate that DS-medicated dual layer PVA patches prepared via a combination of electrospinning and cryogelation are capable of releasing drugs for up to 24 h and can serve as a drug reservoir in the skin, thereby extending the pharmacologic effects of DS.

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“…No skin irritation was observed in animals. 20 Yanping et al (2020), prepared medicament in adhesive transdermal patch for delivering Koumine. Dura-Tak 87-4287.…”

Section: Introductionmentioning

confidence: 99%

Recent advancements in transdermal patches

Sharma

Thakur

Kaur

et al. 2022

ijhs

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Transdermal route of drug administration is novel as well as reliable means of sustained drug delivery. With more and more research being carried out in this field and increasing interest of researchers in this form of drug delivery, number of transdermal devices reaching the marketplace are expected to increase sharply. The aim of this review is to present latest explorations carried out in recent years utilizing possible drug candidates. Also, new polymer candidates along with novel penetration enhancers have been presented. For the purpose of study, various databases viz. Sciencedirect, Web of Knowledge, Pubmed, Google Scholar, etc. have been explored. After going through all the research work done by researchers in recent past it is appropriate to state that transdermal route is no longer reliant on few polymers and penetration enhancers but studies have now provided lot many more options for transdermal device formulation as evident from the data compilations. It can be concluded that most of the researchers have been utilizing HPMC as the preferred film forming polymer but recently use of Eudragit grades also has gained interest amongst scientists.

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Formulation and Evaluation of Zidovudine Transdermal Patch using Permeation Enhancers

Cited by 8 publications

References 8 publications

A Simple Glance at the Transdermal Drug Delivery System

A Simple Glance at the Transdermal Drug Delivery System

Electrospun Nanofiber and Cryogel of Polyvinyl Alcohol Transdermal Patch Containing Diclofenac Sodium: Preparation, Characterization and In Vitro Release Studies

Recent advancements in transdermal patches

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