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The aim of this study was to investigate the chemopreventive efficacy and anti-lipid peroxidative potential of Jasminum grandiflorum Linn. on 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary carcinogenesis. Mammary tumors were developed by a single subcutaneous injection of 25 mg DMBA in 1 mL emulsion of sunflower oil and physiological saline. The tumor incidence and tumor volume that formed in the breast were determined. Oral administration of ethanolic extract of J. grandiflorum flowers (JgEt) at a dose of 300 mg/kg body weight for 14 weeks to DMBA-injected animals completely prevented the formation of tumors in the pre-initiation period. JgEt also exerted significant anti-lipid peroxidative effect and improved the antioxidant defense system in DMBA-treated rats. The results of this study clearly indicate that JgEt has potent chemopreventive efficacy in experimental mammary carcinogenesis and further studies are warranted to isolate and characterize the bioactive principle from JgEt.

The present study examined the relationship between lipid peroxidation and antioxidant status in plasma, erythrocyte and erythrocyte membrane of cervical cancer patients and an equal number of age and sex matched normal subjects as well as patients with cervicitis. Lipid peroxidation was significantly increased with concomitant decrease in antioxidant levels in cervical cancer patients as compared to normal subjects and patients with cervicitis. The elevated lipid peroxidation and disturbed antioxidant status was also noticed in cervicitis patients as compared to normal subjects. This increase in lipid peroxidation can be attributed to possible breakdown of antioxidant mechanisms in cervicitis and cervical cancer patients.

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