Chemopreventive efficacy and anti‐lipid peroxidative potential of <i>Jasminum grandiflorum</i> Linn. on 7,12‐dimethylbenz(a)anthracene‐induced rat mammary carcinogenesis

Kolanjiappan, K; Manoharan, Shanmugam

doi:10.1111/j.1472-8206.2005.00376.x

Cited by 33 publications

(16 citation statements)

References 32 publications

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“…In this study, a significant decrease (p<0,05) was observed in the levels of vitamin C, between control and DMBA groups, which is consistent with Aralkumaran et al Ascorbic acid protects against the genotoxic effects of several radical-generating mutagens, enzymatic superoxidegenerating system (hypoxanthine/xanthine oxidase) DMBA [48]. In another study, researchers demonstrated that Vitamin C, an important extracellular antioxidant, has benefical effects on the conversion of cancerous cells to normal ones and in the lipid peroxidation by product scavenging mechanism [49].…”

Section: Level Of Vitaminssupporting

confidence: 72%

Simultaneous determination of retinol, retinyl palmitate and β-carotene in rat serum treated with 7,12-dimethylbenz[a]anthracene and Hypericum Perforatum L. by high-performance liquid chromatography with diode-array detection

2010

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Simultaneous determination of retinol, retinyl palmitate and β-carotene in rat serum treated with 7,12-dimethylbenz [a]anthracene and Hypericum Perforatum L. by high-performance liquid chromatography with diode-array detection C. Diode-array detection was conducted at 325 and 450 nm for retinol and retinyl palmitate, and β-carotene, respectively with a running time of 26 min. The high-performance liquid chromatography assay and extraction procedure proposed are simple, rapid, sensitive and accurate. This method was then applied to determine the amounts of retinol, retinyl palmitate and β-carotene in rat serum. Results of this study demonstrated that at 60 th day in the 7,12-dimethylbenz[a]anthracene-treated group there was a significant decrease (p<0.001), (p<0,01), (p<0.05) in levels of retinol, retinyl palmitate and vitamin C, respectively compared to the control group levels. A significant decrease (p<0.01) in retinyl palimitate was observed in the 7,12 dimethylbenz [a] anthracene + Hypericum Perforatum L. treated group compared to the control group.. Warsaw and Springer-Verlag Berlin Heidelberg. © Versita

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Section: Level Of Vitaminssupporting

confidence: 72%

Simultaneous determination of retinol, retinyl palmitate and β-carotene in rat serum treated with 7,12-dimethylbenz[a]anthracene and Hypericum Perforatum L. by high-performance liquid chromatography with diode-array detection

2010

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“…This herb is also used as an alternative treatment for cancers and for viral and bacterial infections. Research by Kolanjiappan and Manoharan (2005) demonstrated a strong chemoprevention against experimental mammary carcinogenesis in rats.…”

Section: Introductionmentioning

confidence: 99%

Microbiological Quality of Various Medicinal Herbal Teas and Coffee Substitutes

Tournas

Katsoudas

2008

Microbiol�Insights

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Various herbal teas including German chamomile, Chrysanthemum Vascufl ow herb tea, hop, jasmine and orange fl owers, sweet marjoram, spearmint and thyme leaves, and papaya-mint tea as well as coffee substitutes (Bambu instant Swiss, Teeccino chocolate-mint, and Teeccino Mediterranean Espresso) were analyzed for fungal contamination and the presence of aerobic mesophilic bacteria (APC). The results of this investigation showed that fungal counts reached levels as high as 5.8 × 10 5 colony forming units (cfu) per gram. German chamomile harbored the highest fungal contamination. The most common fungi found in herbal teas were Aspergillus niger, Penicillium spp., Eurotium rubrum, E. chevalieri, A. fl avus, Fusarium spp., Alternaria alternata, and yeasts. Among the coffee substitutes, only the chocolate-mint coffee was contaminated with low numbers (Ͻ1.0 × 10 3 cfu g −1 ) of E. rubrum, Ulocladium spp. and Phoma spp., and with yeasts (Ͻ100-6.8 × 10 3 cfu g −1 ). Aerobic mesophilic bacteria were recovered from 100% of the herbal tea, chocolate-mint and Mediterranean Espresso, and from 50% of the Bambu instant Swiss coffee samples. The highest APC counts of 1.2 × 10 7 cfu g −1 were observed in spearmint leaves.

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“…Mammary carcinogenesis was induced in Sprague-Dawley rats using a single subcutaneous injection of 25 mg of DMBA in 1 ml emulsion of sunflower oil (0.75 ml) and physiological saline (0.25 ml) to each rat (Kolanjiappan and Manoharan, 2005).…”

Section: Induction Of Mammary Carcinogenesismentioning

confidence: 99%

Genistein and Daidzein, in Combination, Protect Cellular Integrity During 7,12-Dimethylbenz[a]anthracene (Dmba) Induced Mammary Carcinogenesis in Sprague-Dawley Rats

Pugalendhi¹,

Manoharan²,

Suresh³

et al. 2011

Afr. J. Trad. Compl. Alt. Med.

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The status of glycoconjugates (protein bound hexose, hexosamine, sialic acid and fucose) in plasma or serum serve as potential biomarkers for assessing tumor progression and therapeutic interventions. Aim of the present study was to investigate the protective effect of two major soy isoflavones, genistein and daidzein, in combination on the status of glycoconjugates in plasma, erythrocyte membrane and mammary tissues during 7,12-dimethylbenz[a]anthracene (DMBA) induced mammary carcinogenesis in female Sprague-Dawley rats. A single subcutaneous injection of DMBA (25 mg rat -1 ) in the mammary gland developed mammary carcinoma in female Sprague-Dawley rats. Elevated levels of plasma and mammary tissue glycoconjugates accompanied by reduction in erythrocyte membrane glycoconjugates were observed in rats bearing mammary tumors. Oral administration of genistein + daidzein (20 mg + 20 mg kg -1 bw/day) to DMBA treated rats significantly (p< 0.05) brought back the status of glycoconjugates to near normal range. The present study thus demonstrated that genistein and daidzein in combination protected the structural integrity of the cell surface and membranes during DMBA-induced mammary carcinogenesis.

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Chemopreventive efficacy and anti‐lipid peroxidative potential of Jasminum grandiflorum Linn. on 7,12‐dimethylbenz(a)anthracene‐induced rat mammary carcinogenesis

Cited by 33 publications

References 32 publications

Simultaneous determination of retinol, retinyl palmitate and β-carotene in rat serum treated with 7,12-dimethylbenz[a]anthracene and Hypericum Perforatum L. by high-performance liquid chromatography with diode-array detection

Simultaneous determination of retinol, retinyl palmitate and β-carotene in rat serum treated with 7,12-dimethylbenz[a]anthracene and Hypericum Perforatum L. by high-performance liquid chromatography with diode-array detection

Microbiological Quality of Various Medicinal Herbal Teas and Coffee Substitutes

Genistein and Daidzein, in Combination, Protect Cellular Integrity During 7,12-Dimethylbenz[a]anthracene (Dmba) Induced Mammary Carcinogenesis in Sprague-Dawley Rats

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