A new type of endovascular prosthesis has been developed using a unique metal alloy (nitinol) with a heat-sensitive memory. Nitinol wire coil grafts were straightened in ice water and passed into the canine aorta via catheter, where they reformed into their original shapes. Follow-up aortograms demonstrated long-term patency with minimal thrombus formation. Nitinol endovascular coil grafts may eventually be used in the nonsurgical treatment of several forms of vascular disease.

Seven children 1-6 years of age underwent aortic resection and re-anastomosis for coarctation of the thoracic aorta. The excised segments were 1-2 cm long and were dilated in vitro with a Grüntzig balloon catheter less than two hours after resection. A pressure of 4-8 atmospheres was used, and the inflated diameter of the balloon was twice the luminal diameter of the undilated coarctation. The diameter of each specimen was increased by an average of 85%, largely because of an increase in the external diameter of the coarctation. However, extremely high pressures were required for successful dilatation, producing transmedial tears in the "normal" aorta distal to the coarctation in three specimens. These results indicate that although balloon dilatation appears feasible as palliation for aortic coarctation, further studies of its safety are necessary before instituting clinical trials.

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Abnormal systemic-to-pulmonary-artery anastomoses can exist in many pathological conditions and result in a left-to-right shunt. Three such conditions are (a) congenital abnormalities, e.g., pulmonary vein atresia, (b) acquired states, e.g., chronic bronchiectasis, and (c) post-surgical states, e.g., a Mustard procedure for complete transposition. Regardless of the etiology, the anastomosis and resulting shunt produce increased oxygen saturation in the ipsilateral pulmonary artery. Four cases are presented, with emphasis on the angiographic and hemodynamic findings.

When significant thoracic vascular anomalies occur in children, they may present surgical difficulties making operative management undesirable. The recent development of a new, accurate coil-delivery system has enabled us to embolize 17 vessels in five children by passing Gianturco steel coils coated with thrombogenic Dacron strands through No. 5 risks and benefits of transcatheter embolization, nor does it permit comparison of the various techniques. This report describes the steel coil embolization of 17 thoracic vessels in five children with a new, accurate coil-delivery system and compares results of that procedure with those of previously described techniques. MethodsFive infants and children were shown at cardiac catheterization to have congenital thoracic vascular anomalies. Findings were reviewed in a combined cardiovascular surgery, vascular radiology, pediatric cardiology conference, and transcatheter embolization was recommended. Patients were recatheterized. Arterial or venous access was gained with a No. 5 or 6F endhole catheter, and embolization was accomplished with Gianturco steel coils, uniformly coated with thrombogenic Dacron strands (figure 1). As previously described,9 coils of 0.038 inch packed diameter were straightened over a thin wire and fed through the catheter lumen by a flexible guidewire, emerging in the abnormal vessel as a loose coil of 3, 5, or 8 mm diameter. Extremely flexible guidewires were used to avoid displacement of the catheter tip during the procedure. After placement of coils, occlusion occurred by thrombosis, generally within 10 min. If complete occlusion was not angiographically apparent 5 or 10 min after initial placement, smaller coils were lodged in the remaining vessel lumen to further obstruct the vessel. The first coil was chosen so that extruded diameter exceeded the angiographically estimated vessel lumen by about 50%.

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To investigate the acute and long-term effects on the vasa vasorum after massive overdilation, canine aortic segments were dilated with Gruentzig balloon catheters to more than 100% over normal size. In the acute study, the significant lumen increase was the result of intimal and medial rupture with stretching and thinning of the adventitia. In these areas, the vasa vasorum were stretched and severed, causing adventitial hemorrhage. In the chronic study, areas of previous subtotal wall rupture with adventitial thinning were repaired by scar tissue. This repair included formation of a neomedia, hyperplasia of the adventitia, and proliferation of the vasa vasorum. No progression of luminal dilatation was seen. This study showed that in subtotal aortic wall rupture, even a severely damaged adventitia is capable of preserving the lumen from further dilatation and rupture until healing. Blood flow to the damaged vessel wall was reestablished by revascularization via capillary budding in the aortic wall.

Retrograde transurethral balloon dilation of the prostatic urethra was performed in five human volunteers with benign prostatic hypertrophy. Each patient underwent cystoscopy, uroflow studies, voiding cystourethrography, retrograde urethrography, and magnetic resonance imaging before dilation and at defined intervals afterward. The longest follow-up to date is 8 months. Patients were given topical anesthetics and mild sedatives, and dilation was performed with a 25-mm urethroplasty balloon catheter inflated at 3-6 atm for 10 minutes. All catheter manipulations were done with a guide wire and under fluoroscopic control. Significant resolution of symptoms of prostatism was seen in four patients. The unsatisfactory results in the last patient were believed to be caused by ineffectual dilation of predominantly middle lobe hypertrophy--a condition that is now regarded as a contraindication to dilation. This technique has promise to replace transurethral resection of the prostate as the treatment of choice for this common male ailment.