Acute and long-term effects of massive balloon dilation on the aortic wall and vasa vasorum.

Zollikofer, Ch. L.; Redha, F.; Brühlmann, W; Uhlschmid, G; Vlodaver, Zeev; Castańeda-Zúńiga, W R; Amplatz, K

doi:10.1148/radiology.164.1.2954183

Cited by 46 publications

(19 citation statements)

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“…30 Previous studies have demonstrated that balloon angioplasty induces stretching and/or rupture of the vasa vasorum, with subsequent hemorrhage at the balloon site. 31 Occlusion of the vasa vasorum induces PDGF synthesis and intimal cell proliferation. 32 Ischemia/reperfusion of the vessel wall after angioplasty caused by occlusion of the vasa vasorum may set in motion a series of events leading to inflammation followed by the proliferation of adventitial and intimal cells.…”

Section: Discussionmentioning

confidence: 99%

Perivascular Inflammation After Balloon Angioplasty of Porcine Coronary Arteries

et al. 2001

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Background-Inflammation has been suggested to play a role in vascular lesion formation after angioplasty. Whereas previous studies have focused on inflammatory reactions in the intima and media, less attention has been paid to adventitial and perivascular responses and their potential role in vascular remodeling. Methods and Results-Balloon overstretch injury of porcine coronary arteries was performed with standard clinical angioplasty catheters. Vessels were examined from 0.5 hour to 14 days after injury by immunohistochemistry and in situ hybridization (ISH) for neutrophil and macrophage markers, cell adhesion molecules (P-selectin, E-selectin, and vascular cell adhesion molecule-1), and neutrophil-specific CXC chemokines (alveolar macrophage-derived neutrophil chemotactic factor [AMCF]-I/interleukin-8 and AMCF-II). Neutrophils accumulated in the adventitia surrounding the injury site from 2 hours to 3 days, followed by macrophages from 1 to 7 days after angioplasty. Inflammation was associated temporally with the expression of mRNAs encoding cell adhesion molecules and chemokines. The main inflammatory and proliferative foci were not limited to the adventitia but rather extended many millimeters away from the injured vessel throughout the surrounding adipose and myocardial tissues. Conclusions-Inflammatory

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Section: Discussionmentioning

confidence: 99%

Perivascular Inflammation After Balloon Angioplasty of Porcine Coronary Arteries

et al. 2001

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“…46 It is now well established that oxygen tension has profound effects on the wound repair response, such that hypoxia induces inflammatory and other mesenchymal cells to secrete growth factors that directly influence proteinase synthesis in cells at the wound site. 33 .…”

Section: Implications Of Proteinase and Inhibitor Location In Aortic mentioning

confidence: 99%

“…In the aortic wall, proliferation of the vasa vasorum is a characteristic feature observed during the repair response to dilation. 46 Neovascularization is known to be associated with both metalloproteinase (CL, GL, and stromelysin) and serine proteinase (tissue plasminogen activator) synthesis and secretion. 32 Induced capillary endothelial cells also secrete large quantities of TIMP.…”

Section: Implications Of Proteinase and Inhibitor Location In Aortic mentioning

confidence: 99%

Connective tissue proteinases and inhibitors in abdominal aortic aneurysms. Involvement of the vasa vasorum in the pathogenesis of aortic aneurysms.

Herron

Unemori

Wong

et al. 1991

Arterioscler Thromb

145

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T he development of irreversible dilations of the infrarenal aorta has been attributed to hemodynamic disturbances as well as to structural and metabolic changes within the vessel wall. 1 -2 Chemical and histological analyses have demonstrated significant decreases in the two major structural proteins, collagen and elastin, in dilated vascular tissue from patients undergoing corrective surgery for abdominal aortic aneurysm (AAA) disease. 34 Experimentally, it has been shown that circumferential arterial wall stress is borne primarily by elastin and that collagen maintains the integrity of the arterial wall, as enzymatic hydrolysis of collagen results in vessel rupture, whereas degradation of

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“…Within the wall of the host blood vessel, a network of microvessels is formed, the vasa vasorum. Despite lying predominantly in the adventitia, in certain large arteries, veins, and atherosclerotic arteries, these microvessels also penetrate the media [2][3][4]. They constitute nutrient vases within the wall of most arteries, including the aorta and coronary arteries, carotids, and femoral arteries [5,6], as well as within some intracerebral arteries and the vena cava [7,8].…”

Section: Introductionmentioning

confidence: 99%

The implication of vasa vasorum in surgical diseases of the aorta

Baikoussis¹,

Apostolakis²,

Papakonstantinou³

et al. 2011

European Journal of Cardio-Thoracic Surgery

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Vasa vasorum (VV) are microscopic vases that perfuse the vessel's wall; arteries and veins. Many recent researches support the opinion that VV have a significant role in aortic pathology. The VV, or 'the vessels of the vessels', form a network of microvessels that lie in the adventitia and penetrate the outer media of the host vessel wall. Although the importance of the VV in providing nutritional support is not well known, obstruction of blood flow through these vessels has been implicated in the pathogenesis of many cardiovascular diseases such as aortic intramural hematoma, aortic aneurysm, and acute or chronic aortic dissection. Although the proliferation of VV due to atherogenic stimuli is controversial, experimental and clinical studies strongly suggest the potential of VV in vascular proliferative disorders. It seems that the rupture of VV is implicated in intramural hematoma, which can develop in acute aortic dissection. In this review article, we would like to stress the anatomy and mainly the pathophysiology, and the implication of VV in the acute and chronic aortic pathologies.

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Acute and long-term effects of massive balloon dilation on the aortic wall and vasa vasorum.

Cited by 46 publications

References 0 publications

Perivascular Inflammation After Balloon Angioplasty of Porcine Coronary Arteries

Perivascular Inflammation After Balloon Angioplasty of Porcine Coronary Arteries

Connective tissue proteinases and inhibitors in abdominal aortic aneurysms. Involvement of the vasa vasorum in the pathogenesis of aortic aneurysms.

The implication of vasa vasorum in surgical diseases of the aorta

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