Background: Aqueous leaf extract of Moringa oleifera (MO) was evaluated for its ability to ameliorateacetaminophen-induced toxicity in albino rats using serum urea and creatinine levels as well as heamatological parameters as indices of evaluation.
Methods: Groups of five Albino rats were pre-administered with MO (200 and 400mg/kg/bw) prior to a single dose administration of acetaminophen (3g/kg body weight). Haematological and biochemical indices were determined using standard methods.
Results: Pretreatment of 200mg and 400 mg/kg body weight prior to acetaminophen administration caused significant reductions(p<0.05) in the test groups when compared to normal control groups in the levels of urea and creatinine in serum. There were no significant difference in the haematological parameters between the test and control groups.
Conclusion: Results suggest that aqueous extract of Moringa oleifera administration would affect biologicalresponse to acetaminophen in kidney functions.
This study was aimed at investigating the anti-bacterial activity of some on shelf herbal medicines for treatment of Cholera and Typhoid in markets. The sample was collected from shops that sell herbal medicines using random sampling to investigate the effectiveness of these herbal medicines on Escherichia coli and Salmonella enterica serotype typhi. It was noticed that all the four herbal medicines that were subjected to antibacterial activities using E. coli and S. typhi, showed effect on the bacteria. Diameters of zones of inhibition was measured, which showed that zone of inhibition varies among the on shelf herbal medicines. Serial dilution was also carried out to check for the effect of concentration. Herbal Medicine for Typhoid 1 showed the highest zone of inhibition 14.36 mm and the lowest zone of inhibition was Herbal Medicine for Cholera 1 with 10.17mm on S. Typhi. While for E. coli, the highest zone of inhibition was 12.83mm shown by Herbal Medicine for Cholera 2 and the lowest was 10.25mm shown by Herbal Medicine for Typhoid 1.
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