Ring closure reactions O 0130Synthesis and Antimicrobial Activity of Some New Cyanopyridine and Cyanopyrans Towards Mycobacterium tuberculosis and Other Microorganisms. -A series of 9 compounds of each type (III), (V), and (VI) is prepared. Some of them show moderate antitubercular or antimicrobial activities. -(VYAS, D. H.; TALA, S. D.; AKBARI, J. D.; DHADUK, M. F.; JOSHI, K. A.; JOSHI*, H. S.; Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 48 (2009) 6, 833-839; Dep. Chem., Saurashtra Univ., Rajkot 360 005, India; Eng.) -M. Bohle 42-024
New series of fused 1,2,4-triazoles, i.e., 3-(4-isopropylphenyl)-6-substituted phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles (5a-5j) have been synthesized via a four-step procedure and using eco-friendly reaction condition at some steps of the synthesis. It was adopted by the formation of hydrazide of methyl 4-isopropylbenzoate (1) followed by reaction with CS2 in basic media to afford potassium salt, which on cyclized to our essential step, 4-amino-5-(4-isopropylphenyl)-4H-1,2,4-triazole-3-thiol (4). The desired adducts (5a-5j) were formed by (4) on reaction with various aromatic acids in POCl3 media. The newly synthesized triazolo- thiadiazoles have been characterized by different spectroscopic techniques and investigated for their in vitro antibacterial and antifungal activity. It was revealed that the compounds 5a, 5c, 5h, and 5i showed interesting antibacterial and antifungal activity compared to the used reference standard.
SynopsisPolyester waste was degraded with ethanol, n-propanol, and benzyl alcohol in an autoclave at 280°C under pressure to give seven unknown compounds. The products of each reaction were isolated by using column chromatography and were identified on the basis of elemental analysis and spectral data.
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