Synthesis of some new 6-aryl-3-(4-isopropylphenyl)[1,2,4]triazolo[3,4-b][1,3,4] thiadiazoles and its anti-microbial study

Abstract

New series of fused 1,2,4-triazoles, i.e., 3-(4-isopropylphenyl)-6-substituted phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles (5a-5j) have been synthesized via a four-step procedure and using eco-friendly reaction condition at some steps of the synthesis. It was adopted by the formation of hydrazide of methyl 4-isopropylbenzoate (1) followed by reaction with CS2 in basic media to afford potassium salt, which on cyclized to our essential step, 4-amino-5-(4-isopropylphenyl)-4H-1,2,4-triazole-3-thiol (4). The desired adducts (5a-5j) were formed by (4) on reaction with various aromatic acids in POCl3 media. The newly synthesized triazolo- thiadiazoles have been characterized by different spectroscopic techniques and investigated for their in vitro antibacterial and antifungal activity. It was revealed that the compounds 5a, 5c, 5h, and 5i showed interesting antibacterial and antifungal activity compared to the used reference standard.

Novel Antitubercular Agents: Design, Synthesis, Molecular Dynamic and Biological Studies of Pyrazole – 1,2,4‐Triazole Conjugates

“…The electronic properties of nitrogen or sulfur heteroatoms are a significant factor in their selection. One of these compounds, 1,2,4-triazole, has demonstrated a wide range of biological activities such as antibacterial, [5][6][7] antimicrobial, [8][9][10] anti-HIV, [11][12][13] antiviral, [14,15] antitumor, [14][15][16] and antitubercular. [17][18][19][20] Researchers have found that modifying the structure of the triazole moiety with specific molecular groups can enhance its biological potency.…”

(Benzylideneamino)triazole–Thione Derivatives of Flurbiprofen: An Efficient Microwave-Assisted Synthesis and In Vivo Analgesic Potential

“…Synthesis of triazoles and their biological importance have received considerable attention in recent years, and this class of compounds have become one of the potential agents for drug discovery. − Among these, 1,2,4-triazoles represent an important class of organic compounds with wide use in medicine, agriculture, and industry . A wide variety of therapeutically interesting drug candidates possessing analgesic, anti-inflammatory, anti-microbial, anti-cancer, anti-depressant, anti-fungal, anti-convulsant, and anti-viral activities are discussed in the literature possessing the 1,2,4-triazole moiety. − …”