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ZusammenfassungDie Folgen der Digitalisierung für die Arbeitsbedingungen sind nicht technisch vorgegeben, sondern gestaltbar. Dazu müssen allerdings die Interessen der Beschäftigten im Strukturwandel auch aktiv eingebracht werden. Auf eine solche aktive Gestaltungspolitik zielt das gemeinsame Projekt NRW Arbeit 2020 von IG Metall, NGG und IG BCE. Die wissenschaftliche Begleitung des Projekts zeigt, dass sich der dialogorientierte Gestaltungswille von Gewerkschaften und Betriebsräten auszahlt. Allerdings sind umfangreiche Beratungen notwendig, die sich nicht ohne weiteres in alle Betriebe übertragen lassen.

Nuclear factor erythroid 2-related factor 2 (Nrf2) is downregulated in chronic kidney disease (CKD). Activation of Nrf2 might be a therapeutic option in CKD. Here we investigate the effect of Nrf2 activation on aldosterone (Aldo)-induced renal injury. Wild-type (WT) mice, transgenic Keap1 hypomorphic (Nrf2ꜛ, genotype results in upregulation of Nrf2 expression) mice and WT mice treated with the Nrf2 activator sulforaphane (Sulf) received Aldo for 4 weeks. In Aldo-treated mice, kidneys were significantly heavier and pathologically altered, reflected by increased urinary albumin levels and tissue damage. Sulf succeeded to decrease albumin excretion. In Nrf2ꜛ-Aldo mice the tubule damage marker NGAL was significantly decreased. Increased oxidative damage markers (8-OHdG, 15-isoprostane F2t) were measured in all Aldo-treated groups. Aldo-increased Nrf2 amounts were mainly found in the late tubule system. The amount of phosphorylated and thus putatively active Nrf2 was significantly increased by Aldo only in WT mice. However, expression of Nrf2 target genes NQO1 and HO1 was decreased in all Aldo-infused mice. GSK3β, which promotes Nrf2 degradation, was significantly increased in the kidneys of Aldo-treated WT mice. Neither genetic nor pharmacological Nrf2 activation was able to prevent oxidative injury induced by Aldo, probably due to induction of negative regulators of Nrf2.

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