Background: Although several research efforts have been made worldwide to discover novel drug candidates for the treatment of Chagas disease, the nitroimidazole drug benznidazol remains the only therapeutic alternative in the control of this disease. However, this drug presents reduced efficacy in the chronic form of the disease and limited safety after long periods of administration, making it necessary to search for new, more potent and safe prototypes. Objective: We described herein the synthesis and the trypanocidal action of new functionalized carbohydrazonamides (2-10) against trypomastigote forms of Trypanosoma cruzi. Methods: These compounds were designed through the application of molecular hybridization concept between of two potent anti-T. cruzi prototypes, the nitroimidazole derivative megazol (1) and the cinnamyl N-acylhydrazone derivative (14) which has been shown to be twice as potent in vitro as benznidazole. Results: The most active compounds were the (Z)-N'-((E)-3-(4-nitrophenyl)-acryloyl)-1-methyl-5-nitro-1H-imidazol-2-carbohydrazonamide (6) (IC50 9.50 μM) and the (Z)-N'-((E)-3-(4-hydroxyphenyl)-acryloyl)-1-methyl-5-nitro-1H-imidazol-2-carbohydrazonamide (8) (IC50 12.85 μM), which were almost equipotent to benznidazole (IC50 10.26 μM) used as standard drug. The removal of the amine group attached to the imine subunit in the corresponding N-acylhydrazone derivatives (11-13) resulted in less potent or inactive compounds. The para-hydroxyphenyl derivative (8) presented also a good selectivity index (SI = 32.94) when tested against mammalian cells from Swiss mice. Conclusions: The promissing trypanocidal profile of new carbohydrazonamide derivatives (6) and (8) was characterized. These compounds have proved to be a good starting point for the design of more effective trypanocidal drug candidates.
Background: Approximately, 5-7 million people are infected with T. cruzi in the world, and approximately 10,000 people per year die of complications linked to this disease. Method: This work describes the construction of a new family of hidrazonoyl substituted derivatives, structurally designed exploring the molecular hybridization between megazol and nitrofurazone. Results and Discussion: The compounds were evaluated for their in vitro activity against bloodstream trypomastigotes of Trypanosoma cruzi, etiological agent of Chagas disease, and for their potential toxicity to mammalian cells. Conclusion: Among these hydrazonoyl derivatives, we identified the derivative (4) that showed trypanocidal activity (IC50/24 h = 15.0 µM) similar to Bz, the standard drug, and low toxicity to mammalian cells, reaching an SI value of 18.7.
The participation of the organizational psychologist defines the quality and productivity of the organization,becoming an important member of the company's human capital.The objective of this article is to demonstrate the importance of the psychologist in the recruitment and selection of employees of organizations, developing it with a qualitative approach in a bibliographical research. The scientific platform of Google Scholar, Scielo, MedLine and Capes Periodicals was used to survey sources of queries,limiting the search to books,academic papers and scientific articles produced in the last 5 years. The following keywords were also used: psychologist; recruitment and selection; organizations.The results indicate that the organizational psychologist has the important task of guiding their leaders to manage people in line with organizational goals,as much as current employees offer an improvement in the company's quality of life,well-being and the comfort of capital human,but also actively participating in the processes of recruitment and selection of new employees so that they are aligned with the objectives proposed by the organization, always seeking to generate results within the organization and maintain a balanced behavioral environment that is pleasant to all employees.
Introdução: A análise das limitações dos movimentos mandibulares representa um importante sinal para a compreensão do diagnóstico de alterações funcionais do sistema estomatognático. Atualmente um dos principais instrumentos utilizados por fisioterapeutas, odontólogos e fonoaudiólogos para avaliação e mensuração dos movimentos mandibulares é o paquímetro, um instrumento não invasivo e de fácil utilização que oferece medidas objetivas na avaliação do sistema estomatognático. Objetivo: Avaliar a confiabilidade intra e interexaminadores da avaliação dos movimentos mandibulares por meio do paquímetro. Métodos: Trata-se de um estudo com delineamento transversal e de caráter comparativo realizado em indivíduos entre 18 e 25 anos com grau leve ou sem sintomas de DTM de acordo com o ProDTMMulti. A coleta foi realizada em dois dias de mensuração dos movimentos mandibulares de abertura, protrusão, lateralidade direita e esquerda para cada examinado por meio do paquímetro analógico de plástico. A análise de concordância foi calculada pelo Coeficiente de Correlação Intraclasse (ICC), onde foi adotado um nível de significância de 5%. Resultados e Discussão: O paquímetro é um instrumento confiável e apresenta uma excelente confiabilidade intraexaminador para quase todos os movimentos, exceto desvio lateral esquerdo que demonstrou uma moderada confiabilidade e a confiabilidade interexaminadores foi moderada para maioria dos movimentos. Conclusão: Pode-se concluir que o paquímetro é um método confiável para analises intra-examinadores, no entanto, isso não ocorre para avaliações inter-examinadores, onde apresenta confiabilidade moderada, além de apresentar grande utilidade para a aplicação clínica que envolva um ou mais examinadores durante o atendimento.
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