The nature of ileus and the clinical problem it poses are discussed. A consideration of the previous multiplicity of treatments is presented. The concepts behind the present mode of treatment are outlined. This consists of removing the sympathetic inhibition of the alimentary tract in the condition and potentiating or supplementing tone. Case histories are presented to illustrate the use of the drugs suggested, and the indications for therapy are discussed. The mistaken concept that the gut is “paralysed” in ileus should be finally abandoned.

EDITORIAL COMMENT These observations in the cat show that the stomach has a high level of extrinsic, and a low level of intrinsic, cholinergic control, but this is reversed in the small intestine. Similar studies are clearly needed in man to provide us with logical tests for the management of motility disorders.

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