An analysis of the autonomic control of gastrointestinal motility in the cat.

Neely, Julian; Catchpole, B. N.

doi:10.1136/gut.8.3.230

Cited by 37 publications

(14 citation statements)

References 41 publications

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“…This finding is in agreement with previous reports which outlined the existence of intestin al movements early in the postoperative period with various techniques: balloon kymography [19,20,22], radiological methods [16,18,21] or study of abdominal sounds [1,6,25,27]. Therefore, it may be suggest ed that the 'physiological' ileus is not due to the disappearance of intes tinal mechanical activities but to their disorganization.…”

Section: Discussionsupporting

confidence: 82%

Effects of Some Drugs on Electrical Activity of the Gut in the Postoperative Period

Dauchel¹,

Schang²,

Kachelhoffer³

et al. 1976

Eur Surg Res

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Myoelectrical activity of the gut has been studied in the postoperative period on 54 patients who underwent cholecystectomy. They have been divided into one control group and four other groups which were treated with pentagastrin, cholecystokinin, prostigmine or coherin (a posterior pituitary extract). In all patients, bursts of spikes were recorded during the early postoperative period. However, the slow waves were strongly disturbed at this time. Pentagastrin, CCK-PZ and prostigmine had no effect on the slow waves, while they increased the frequency of the spikes. These substances did not reduce the duration of the ‘physiological’ ileus. On the contrary, coherin was found to improve the regularity of the slow waves and to reduce the duration of the ‘physiological’ ileus.

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Section: Discussionsupporting

confidence: 82%

Effects of Some Drugs on Electrical Activity of the Gut in the Postoperative Period

Dauchel¹,

Schang²,

Kachelhoffer³

et al. 1976

Eur Surg Res

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“…These findings have been confirmed repeatedly (Nachlas, Younis, Roda, and Wityk, 1972;Neely, 1968). Most of these studies have been radiological observations of barium in the gastrointestinal tract, and, althoughthestudies have been primarily directed at the stomach, most workers have observed that barium is also held up in the colon.…”

mentioning

confidence: 60%

“…It has been shown in experimental animals that the activity of the small intestine returns to normal within a few hours following surgery (Tinckler, 1965;Baker and Webster, 1968). Early return of activity has also been shown in man using a radiotelemetering capsule (Ross, Watson, and Kay, 1963 (Nachlas, Younis, Roda, and Wityk, 1972;Neely, 1968). Most of these studies have been radiological observations of barium in the gastrointestinal tract, and, althoughthestudies have been primarily directed at the stomach, most workers have observed that barium is also held up in the colon.…”

mentioning

confidence: 99%

Postoperative motility of the large intestine in man.

Wilson¹

1975

Gut

139

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SUMMARY Motor activity of the colon in the immediate postoperative period has been studied in human subjects using radiotelemetering capsules, radioopaque markers and serial abdominal radiographs.Following operations outside the abdomen there is a delay of about 16 hours before colonic activity returns. After abdominal operations the delay is from 40 to 48 hours.The length of an operation has no significant effect upon the duration of colonic ileus. The amount of postoperative analgesia has no significant effect upon the duration of colonic ileus. Gaseous distension after laparotomy is confined to the colon.It is well recognized that following operation the motility of the gastrointestinal tract is temporarily impaired. At times this is more prolonged and, if associated with gaseous distension, develops into paralytic ileus. It has been shown in experimental animals that the activity of the small intestine returns to normal within a few hours following surgery (Tinckler, 1965;Baker and Webster, 1968). Early return of activity has also been shown in man using a radiotelemetering capsule (Ross, Watson, and Kay, 1963 (Nachlas, Younis, Roda, and Wityk, 1972;Neely, 1968). Most of these studies have been radiological observations of barium in the gastrointestinal tract, and, althoughthestudies have been primarily directed at the stomach, most workers have observed that barium is also held up in the colon. Study of the colon has not been taken further than this one observation.The present study investigates in more detail the motor behaviour of the colon in the postoperative

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“…The mode of action of glucagon differs from other mediators of colonic relaxation. For instance, atropine acts by competitive blockade at postganglionic parasympathetic junctions and is known to inhibit colonic motility in vitro (Neely and Catchpole, 1967) and in vivo (Misiewicz, 1974). However, in doing so, it preserves the regular slow wave activity and has no effect on either its frequency, amplitude, or incidence (Taylor, 1974).…”

Section: Discussionmentioning

confidence: 99%

“…Using a cat colon model in situ, Neely and Catchpole (1967) showed that sympathetic inhibition was mediated mainly through P receptors.…”

Section: Discussionmentioning

confidence: 99%

Glucagon and the colon.

Taylor¹,

Duthie²,

Cumberland³

et al. 1975

Gut

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SUMMARY The effect of glucagon on human colonic myoelectrical activity is described. By means of intraluminal, serosal, and surface electrodes, recordings from all areas of the large bowel have been obtained. Glucagon inhibited both electrical and pressure rhythms in all subjects tested. Evidence is produced to suggest a direct action on colonic smooth muscle. A controlled trial using glucagon during routine barium enema examinations suggests that it may prove to be useful for hypotonic examinations of the colon where painful spasm is present.

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An analysis of the autonomic control of gastrointestinal motility in the cat.

Cited by 37 publications

References 41 publications

Effects of Some Drugs on Electrical Activity of the Gut in the Postoperative Period

Effects of Some Drugs on Electrical Activity of the Gut in the Postoperative Period

Postoperative motility of the large intestine in man.

Glucagon and the colon.

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