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A case of metastatic carcinoid syndrome with hypoxaemia is described. The hypoxaemia appeared to be due to intrapulmonary shunting. There was improvement in resting and exercise arterial oxygen saturations following chemotherapy with streptozotocin and 5-fluorouracil. This was followed by a decrease in the tumour bulk which may have led to a reduction in the secretion of the vasodilator products responsible for shunting. Some features of this case suggest that the hypoxaemia might have been due to dilatation of precapillary and capillary vessels of the pulmonary micro-circulation. These features are part of the so-called 'hepatopulmonary syndrome', of which this case appears to represent a less severe form.

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fection. The femoral vein is very small in rats. We were not able to locate it without cutting the skin. The jugular vein is by far the largest of the peripheral vessels of the rat. Blood may be drawn from it without much difficulty because of the ease in locating it by its pronounced pulsation. The jugular vein of the rat runs anteriorly over the clavicle about 10 mm. from the middle of the sternum.If a rat is given a little ether, placed on its back on a board and tied so that the head is approximately one inch lower than the rest of the body, the hair clipped over the clavicle, it is easy to locate the jugular by the pulsation and to feel the clavicle. With the clavicle to support the vessel and the pulsation to direct us, it is not difficult to place the needle into the vessel. This same route has been used by us for injecting various substances and also for transfusing rats. It has also been found possible to collect blood from rats according to the above technique without the use of an anesthetic. 5892Studies on Calcium and Phosphorus in Bile-fistula Dogs.

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