The Rôle Played by Bile in the Absorption of Vitamin D in the Rat

Greaves, Joseph D.; Schmidt, Carl F.

doi:10.1016/s0021-9258(18)50218-0

Journal of Biological Chemistry

1933

DOI: 10.1016/s0021-9258(18)50218-0

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The Rôle Played by Bile in the Absorption of Vitamin D in the Rat

Joseph D. Greaves

Carl F. Schmidt

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1935

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Cited by 51 publications

(1 citation statement)

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“…This osteoporosis will develop after several months (8 to 12) with a bile fistula given no 90 HEMOGLOBIN PRODUCTION IN ANEMIA bile by mouth or in a dog with complete biliary obstruction. The osteoporosis develops because of lack of absorption of vitamin D and this state is corrected or prevented by the presence of bile salts in the intestine (1).…”

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Hemoglobin Production in Anemia as Influenced by the Bile Fistula

Hawkins

Robscheit‐Robbins

Whipple

1938

Journal of Experimental Medicine

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The presence of a renal bile fistula with escape of all bile into the urinary tract seriously impairs the capacity of an anemic dog to form new hemoglobin on standard diets. These bile fistula dogs will produce about one-half as much hemoglobin in anemia on standard diets as during earlier control periods without a bile fistula. Iron given by mouth to an anemic bile fistula dog will effect the production of about one-half the amount of new hemoglobin as in control periods. Iron given by vein to an anemic bile fistula dog will approximate the theoretical 100 per cent return of new hemoglobin. Obviously absorption is a very important factor in the utilization of iron by these dogs. The reaction to liver feeding is much like the reaction to iron feeding but we have no proof of inadequate protein digestion and absorption in these bile fistula dogs. In fact the uniform body weight and normal clinical state over periods of years speak for adequate absorption of protein digestion products. Evidence cited above supports our belief that inadequate hemoglobin production (protein formation) noted in these bile fistula dogs may be related to a disturbed liver function.

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Hemoglobin Production in Anemia as Influenced by the Bile Fistula

Hawkins

Robscheit‐Robbins

Whipple

1938

Journal of Experimental Medicine

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Liver and Biliary Tract

Greene¹

1936

Arch Intern Med (Chic)

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Liver and Biliary Tract

Greene¹

1939

Arch Intern Med (Chic)

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The Rôle Played by Bile in the Absorption of Vitamin D in the Rat

Cited by 51 publications

References 23 publications

Hemoglobin Production in Anemia as Influenced by the Bile Fistula

Hemoglobin Production in Anemia as Influenced by the Bile Fistula

Liver and Biliary Tract

Liver and Biliary Tract

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