BackgroundHuntington's disease (HD) is a fatal inherited neurodegenerative disease, caused by a

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Background and purpose In Parkinson's disease (PD), the course of the disorder is highly variable between patients. Well‐designed, prospective studies for identifying PD progression biomarkers are necessary. Our aim was to show the results of baseline evaluations of an ongoing global PD project, COPPADIS‐2015 (Cohort of Patients with PArkinson's DIsease in Spain, 2015). Methods This was an observational, descriptive, nationwide study (Spain). The recruitment period ended in October 2017. Baseline evaluation included more than 15 validated scales and complementary studies in a subgroup of participants. Results In total, 1174 subjects from 35 centres were considered valid for baseline analysis: 694 patients (62.6 ± 8.9 years old, 60.3% males), 273 caregivers (58.5 ± 11.9 years old, 31.8% males) and 207 controls (61 ± 8.3 years old, 49.5% males). The mean disease duration was 5.5 ± 4.4 years. Hoehn and Yahr stage was 1 or 2 in 90.7% of the patients whilst 33.9% and 18.1% of them presented motor fluctuations and dyskinesias, respectively. The mean Non‐Motor Symptoms Scale total score was 45.4 ± 38.1, and 30.4% of the patients presented cognitive impairment, 16.1% major depression, 12.7% impulse control disorder, 7.2% compulsive behaviour, 57.2% pain and 13.2% falls. Compared to the control group, PD patients presented a significantly higher burden of non‐motor symptoms and a worse quality of life. More than 300 subjects conducted complementary studies (serum biomarkers, genetic and neuroimaging). Conclusions Parkinson's disease is a complex disorder and different non‐motor symptoms are frequently present and are more prevalent than in controls. In real clinical practice it is important to ask for them.

Resumen. La música está presente en todas las culturas y, desde edades tempranas, todas las personas tenemos las capacidades básicas para su procesamiento, el cual está organizado en módulos diferenciados que implican distintas regiones cerebrales. ¿Forman estas regiones rutas específicas del procesamiento musical? Como veremos, la producción y percepción musical implican gran parte de nuestras capacidades cognitivas, involucrando áreas del córtex auditivo y del córtex motor. Por otro lado, la música produce en nosotros respuestas emocionales que involucran distintas áreas corticales y subcorticales. ¿Se trata de las mismas rutas implicadas en el procesamiento de las emociones en general? Revisamos la bibliografía existente sobre estas cuestiones, así como las diferentes alteraciones neurológicas musicales que existen, desde la epilepsia musicogénica hasta la amusia, así como las diferentes posibilidades de tratamiento. Palabras clave. Alucinación musical. Amusia. Distonía del músico. Emoción. Interacción auditivomotora. Memoria musical.

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