The glycocalyx of epidermal keratinocytes from psoriatic patients has been investigated by means of lectins. Striking changes were found in the levels of glucose and/or mannose (concanavalin A) and of N-acetylglucosamine and/or sialic acid (wheat germ agglutinin) on the surface of cells from the psoriatic lesion. Smaller but significant changes were seen in the clinically uninvolved epidermis of the patient. A marked increase in the affinity of the cell surface for Ulex europus agglutinin (fucose-specific) confirms our previous reports of structural alterations in fucose-containing oligosaccharides in psoriasis.
Summary.— The Km of the enzyme glucose‐6‐phosphate dehydrogenase for its substrate glucose‐6‐phosphate has been determined in normal human skin and skin from lichen planus patients. There was a clear difference between the 2 groups comparable to that found in congenital erythrocyte glucose‐6‐phosphate dehydrogenase deficiency. The results are discussed in relation to the aetiology and clinical picture of lichen planus.
Лап allen, die op enigerleiwijze hebben bijgedragen aan het tot stand komen van dit proefschrift, mijn oprechte dank.
The present investigations have been carried out in the
Five distinct ester hydrolases (EC 3-1) have been characterized in guinea-pig epidermis. These are carboxylic esterase, acid phosphatase, pyrophosphatase, and arylsulphatase A and B. Their properties are consistent with those of lysosomal enzymes.
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